Curated repository for small angle scattering data and models


SASBDB currently contains:


2767

experimental data sets

3912

models
504 experimental data sets on hold
612 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDNV5 – Botulinum Toxin E at acidic pH

Botulinum Toxin Serotype E, endonegative experimental SAS data
GROMACS model
Sample: Botulinum Toxin Serotype E, endonegative monomer, 144 kDa Clostridium botulinum protein
Buffer: 10 mM sodium acetate (20 mM ionic strength), pH: 4
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Oct 6
Elucidation of critical pH-dependent structural changes in Botulinum Neurotoxin E. J Struct Biol :107876 (2022)
Lalaurie CJ, Splevins A, Barata TS, Bunting KA, Higazi DR, Zloh M, Spiteri VA, Perkins SJ, Dalby PA
RgGuinier 4.3 nm
Dmax 15.2 nm
VolumePorod 240 nm3

Glutathione S-transferase/RNA recognition motif (RRM)-containing protein 4 fusion
RNA recognition motif (RRM)-containing protein 4 experimental SAS data
A MademoiseLLE domain binding platform links the key RNA transporter to endosomes PLOS Genetics 2022 Jun 21 18(6):e1010269
PLOS Genetics 18(6):e1010269 (2022 Jun 21)
Full length apo-polyketide synthase Pks13(S1533A) with Ser801 loaded by a C16-carbon chain
Polyketide synthase Pks13 experimental SAS data
Solution structure of the type I polyketide synthase Pks13 from Mycobacterium tuberculosis. BMC Biol 2022 Jun 21;20(1):147
BMC Biol 20(1):147 (2022 Jun 21)
A recoverin homology domain with EF hand domain of diacylglycerol kinase alpha under the condition without CaCl2
Diacylglycerol kinase alpha experimental SAS data
Ca 2+ ‐induced structural changes and intramolecular interactions in N‐terminal region of diacylglycerol kinase alpha Protein Science 2022 Jun 16 31(7)
Protein Science 31(7) (2022 Jun 16)
Plasmodium falciparum Glycogen Synthase Kinase 3 - Ion Exchange Chromatography Fraction 1
Glycogen synthase kinase 3 experimental SAS data
N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum. Biochem J 2022 Feb 11;479(3):337-356
Biochem J 479(3):337-356 (2022 Feb 11)
Transcription elongation factor SPT6
Transcription elongation factor SPT6 experimental SAS data
Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly. Nucleic Acids Res 2022 May 30;
Nucleic Acids Res (2022 May 30)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.