Small Angle Scattering Biological Data Bank SASBDB

Browse by MODEL: Hybrid

SASDU98 – SEC-SAXS of the fusion protein MPB-MabR(Rv2242) - dimeric peak

Maltose/maltodextrin-binding periplasmic protein (D108A, K109A, E198A, N199A, K265A)Uncharacterized protein Rv2242 experimental SAS data

Sample:	Maltose/maltodextrin-binding periplasmic protein (D108A, K109A, E198A, N199A, K265A) dimer, 80 kDa Escherichia coli (strain … protein Uncharacterized protein Rv2242 dimer, 86 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	50 mM Tris pH 7.5, 150 mM NaCl, pH:
Experiment:	SAXS data collected at SWING, SOLEIL on 2024 Apr 3

Domain architecture of the Mycobacterium tuberculosis MabR (Rv2242), a member of the PucR transcription factor family Heliyon :e40494 (2024)
Megalizzi V, Tanina A, Grosse C, Mirgaux M, Legrand P, Mirandela G, Wohlkönig A, Bifani P, Wintjens R

R_g^Guinier	3.7	nm
D_max	10.8	nm
Volume^Porod	345	nm³

SASDUA8 – SEC-SAXS of the fusion protein MPB-MabR(Rv2242) - tetrameric peak

Sample:	Maltose/maltodextrin-binding periplasmic protein (D108A, K109A, E198A, N199A, K265A) tetramer, 161 kDa Escherichia coli (strain … protein Uncharacterized protein Rv2242 tetramer, 171 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	50 mM Tris pH 7.5, 150 mM NaCl, pH:
Experiment:	SAXS data collected at SWING, SOLEIL on 2024 Apr 3

R_g^Guinier	5.2	nm
D_max	15.8	nm
Volume^Porod	826	nm³

SASDX52 – Fatty acyl-CoA synthetase FadD5

Probable fatty-acid-CoA ligase FadD5 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) experimental SAS data

Sample:	Probable fatty-acid-CoA ligase FadD5 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) dimer, 123 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM HEPES, 500 mM NaCl, 5 mM MgCl2, 1 mM β-mercaptoethanol, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Oct 20

Structural enzymological studies of the long chain fatty acyl-CoA synthetase FadD5 from the mce1 operon of Mycobacterium tuberculosis. Biochem Biophys Res Commun 769:151960 (2025)
Rahman MA, Dalwani S, Venkatesan R

R_g^Guinier	3.6	nm
D_max	12.3	nm
Volume^Porod	221	nm³

SASDX62 – Fatty acyl-CoA synthetase FadD5 with 2 mM ATP

Sample:	Probable fatty-acid-CoA ligase FadD5 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) dimer, 123 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM HEPES, 500 mM NaCl, 5 mM MgCl2, 1 mM β-mercaptoethanol, 2mM ATP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Oct 20

R_g^Guinier	3.6	nm
D_max	12.1	nm
Volume^Porod	213	nm³

SASDX72 – Fatty acyl-CoA synthetase FadD5 with 2 mM coenzyme A (CoA)

Sample:	Probable fatty-acid-CoA ligase FadD5 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase) dimer, 123 kDa Mycobacterium tuberculosis (strain … protein
Buffer:	20 mM HEPES, 500 mM NaCl, 5 mM MgCl2, 1 mM β-mercaptoethanol, 2 mM coenzyme A (CoA), pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2022 Oct 20

R_g^Guinier	3.7	nm
D_max	12.0	nm
Volume^Porod	210	nm³

SASDV75 – S9 carboxypeptidase from Bacillus subtilis (4 mg/ml)

Putative acylaminoacyl-peptidase experimental SAS data

Sample:	Putative acylaminoacyl-peptidase tetramer, 293 kDa Bacillus spizizenii (strain … protein
Buffer:	10 mM Tris-HCl, 135 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL-18, INDUS-2 on 2024 Mar 18

Structural adaptations for carboxypeptidase activity in putative S9 acylaminoacyl peptidase from Bacillus subtilis. Int J Biol Macromol :136734 (2024)
Chandravanshi K, Singh R, Kumar A, Bhange GN, Kumar A, Makde RD

R_g^Guinier	5.2	nm
D_max	15.9	nm
Volume^Porod	439	nm³

SASDV85 – S9 carboxypeptidase from Bacillus subtilis (6 mg/ml)

Sample:	Putative acylaminoacyl-peptidase tetramer, 293 kDa Bacillus spizizenii (strain … protein
Buffer:	10 mM Tris-HCl, 135 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL-18, INDUS-2 on 2024 Mar 18

R_g^Guinier	5.2	nm
D_max	14.7	nm
Volume^Porod	435	nm³

SASDV95 – S9 carboxypeptidase from Bacillus subtilis (8 mg/ml)

Sample:	Putative acylaminoacyl-peptidase tetramer, 293 kDa Bacillus spizizenii (strain … protein
Buffer:	10 mM Tris-HCl, 135 mM NaCl, pH: 8
Experiment:	SAXS data collected at BL-18, INDUS-2 on 2024 Mar 18

R_g^Guinier	5.2	nm
D_max	15.3	nm
Volume^Porod	446	nm³

SASDU52 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, apo form

Sample:	Cereblon-midi monomer, 37 kDa protein
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders Nature Communications 15(1) (2024)
Kroupova A, Spiteri V, Rutter Z, Furihata H, Darren D, Ramachandran S, Chakraborti S, Haubrich K, Pethe J, Gonzales D, Wijaya A, Rodriguez-Rios M, Sturbaut M, Lynch D, Farnaby W, Nakasone M, Zollman D, Ciulli A

R_g^Guinier	2.7	nm
D_max	8.6	nm
Volume^Porod	61	nm³

SASDU62 – Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Mezigdomide

Cereblon-midimezigdomide experimental SAS data

Sample:	Cereblon-midi monomer, 37 kDa protein Mezigdomide monomer, 1 kDa synthetic construct
Buffer:	20 mM Hepes, 500 mM NaCl, 0.5 mM TCEP, pH: 7.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2023 Mar 1

R_g^Guinier	2.3	nm
D_max	7.3	nm
Volume^Porod	60	nm³

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