{"code":"SASDWX2","status":"Published","type_of_curve":"SEC-SAS","angular_unit":"1/A","project":{"title":"Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.","publication":{"title":"Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.","author_list":"Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I","journal":"Nat Commun","doi":"10.1038/s41467-025-58773-8","pmid":"40221417","published_date":"2025 Apr 12"},"status":"released","submitted_date":"2023-07-12","released_date":"2025-02-25"},"pddf_data":"https://www.sasbdb.org/media/p_of_R_files/SASDWX2.out","intensities_data":"https://www.sasbdb.org/media/intensities_files/SASDWX2.dat","intensities_log_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDWX2_dat_img.png","intensities_kratky_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDWX2_kratky_img.png","pddf_plot":"https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDWX2_pofr_img.png","intensities_guinier_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDWX2_guinier_img.png","sascif_data":"https://www.sasbdb.org/media/sascif/sascif_files/SASDWX2.sascif","experiment":{"instrument":{"detector":{"type":null,"name":"Pilatus3 2M","resolution":0.172},"name":"ESRF","city":"Grenoble","country":"France","beamline_name":"BM29","beam_geometry":"point","type_of_source":"X-ray synchrotron","point_source":null,"line_collimation":null,"sample_path_length":null,"line_collimation_slitlength":null,"line_collimation_integrationwidth":null,"xray_energy":null,"beam_profile_ah":null,"beam_profile_al":null},"sample":{"molecule":[{"long_name":"Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S","short_name":null,"sequence":"QVQLKQSGPGLVQPSQTLSITCTVSGFSLTSYGVHWVRQSPGKGLEWLGVIWSGGITDYNAAFISRLSISKDNSKSQVFFKVNSLQPNDTAIYYCARNGRIGSTMTLYYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKSCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK","organism":"Homo sapiens","uniprot_code":null,"uniprot_range_first":null,"uniprot_range_last":null,"oligomerization":"dimer","molecular_type":"protein","uniprot_sequence":"","mw":49.42,"total_mw":98.84,"number_molecules":2,"complex_state":false,"deuteration":null,"molecule_source":"biological","molecule_description":""},{"long_name":"Human immunoglobulin SAP1.3 - kappa chain C214S","short_name":null,"sequence":"DIVMTQAAFSNPVTLGTSASISCRSSKSLLHSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSSSGSGTDFTLRISRVEAEDVGVYYCAQNLELPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGES","organism":"Homo sapiens","uniprot_code":null,"uniprot_range_first":null,"uniprot_range_last":null,"oligomerization":"dimer","molecular_type":"protein","uniprot_sequence":"","mw":23.891,"total_mw":47.782,"number_molecules":2,"complex_state":false,"deuteration":null,"molecule_source":"biological","molecule_description":""}],"buffer":{"name":"50 mM HEPES, 150 mM KCl","concentration_unit":null,"comment":null,"additive":null,"concentration":null,"pka":null,"ph":7.5,"deuteration":null},"purity_method":null,"name":"Human immunoglobulin gamma 2 (IgG2) SAP1.3 - heavy chain C226S kappa chain C214S mutant","ext_coefficient":null,"contrast":null,"specific_vol":null,"dry_vol":null,"absorbption":null,"deuteration":null,"mixture":null},"contributor":[{"affiliation":[{"short_name":null,"address":"Southampton, UK","full_name":"University of Southampton","webpage":"https://www.southampton.ac.uk/"}],"contributor_name":"Isabel","contributor_surname":"Elliott","orcid":"https://orcid.org/0000-0003-4535-5932"}],"concentration_method":null,"concentration_unit":null,"date":"2024-09-28","storage_temperature":3.7,"cell_temperature":20.0,"exposure_time":2.0,"number_of_frames":600,"wavelength":0.099,"sample_detector_distance":2.7,"concentration_min":null,"concentration_max":9.3,"sample_volume":45.0,"flow_rate":0.25,"s_min":0.06,"s_max":4.959,"total_exposure_time":null,"seccolumn":10},"fits":[],"estimated_volume_method":null,"pddf_software":"ATSAS GNOM","pddf_software_version":"4.0.1-1","i0_calibration_standard":null,"description":null,"experiment_description":null,"tags":[],"intensity_unit":"arbitrary","experimental_mw":146.8,"experimental_mw_error":null,"guinier_i0_mw":null,"guinier_i0_mw_error":null,"porod_mw":153.0,"porod_mw_error":null,"pddf_i0":211.0,"pddf_i0_error":0.2048,"guinier_i0":211.116,"guinier_i0_error":null,"pddf_rg":4.91,"pddf_rg_error":0.006,"guinier_rg":4.897,"guinier_rg_error":0.092,"pddf_dmax":15.8,"pddf_dmax_error":null,"porod_volume":213.0,"porod_volume_error":null,"estimated_volume":null,"estimated_volume_error":null,"guinier_point_first":2,"guinier_point_last":42,"pddf_point_first":null,"pddf_point_last":null,"i0_calibration_standard_data":null,"intensities_log_log_plot":"SASDWX2_datloglog_img.png","symmetry":null,"last_modified":"2026-03-06T17:19:16.547548+01:00","bragg_peak":[]}