{"code":"SASDXV3","status":"Published","type_of_curve":"Single concentration","angular_unit":"1/A","project":{"title":"DNA induces non-canonical dimerization of the farnesoid X receptor.","publication":{"title":"DNA induces non-canonical dimerization of the farnesoid X receptor.","author_list":"Khan SH, Yennawar N, Okafor CD","journal":"Nucleic Acids Res","doi":"10.1093/nar/gkag087","pmid":"41728955","published_date":"2026 Feb 5"},"status":"released","submitted_date":"2025-04-16","released_date":"2026-02-26"},"pddf_data":"https://www.sasbdb.org/media/p_of_R_files/SASDXV3.out","intensities_data":"https://www.sasbdb.org/media/intensities_files/SASDXV3.dat","intensities_log_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDXV3_dat_img.png","intensities_kratky_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDXV3_kratky_img.png","pddf_plot":"https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDXV3_pofr_img.png","intensities_guinier_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDXV3_guinier_img.png","sascif_data":"https://www.sasbdb.org/media/sascif/sascif_files/SASDXV3.sascif","experiment":{"instrument":{"detector":{"type":"Hybrid Photon Counting (HPC) X-ray detector","name":"Rigaku HyPix-3000","resolution":100.0},"name":"Pennsylvania State University","city":"University Park, PA","country":"USA","beamline_name":"Rigaku 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receptor","short_name":"FXR","sequence":"KKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFT","organism":"Homo sapiens","uniprot_code":"Q96RI1","uniprot_range_first":110,"uniprot_range_last":466,"oligomerization":"dimer","molecular_type":"protein","uniprot_sequence":"MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ\nISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR\nIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ\nECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTT\nKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQ\nVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSG\nISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQ\nKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ","mw":41.264,"total_mw":82.528,"number_molecules":2,"complex_state":false,"deuteration":null,"molecule_source":"biological","molecule_description":""}],"buffer":{"name":"50 mM HEPES, 150 mM NaCl, 5 % glycerol, 1 mM DTT, 20 µM CDCA","concentration_unit":null,"comment":null,"additive":null,"concentration":null,"pka":null,"ph":7.4,"deuteration":null},"purity_method":null,"name":"Farnesoid X receptor homo-dimer bound to inverted repeat DNA","ext_coefficient":null,"contrast":null,"specific_vol":null,"dry_vol":null,"absorbption":null,"deuteration":null,"mixture":null},"contributor":[{"affiliation":[{"short_name":"PSU","address":"Pennsylvania, USA","full_name":"Pennsylvania State University (PSU)","webpage":"https://www.psu.edu/"}],"contributor_name":"Neela","contributor_surname":"Yennawar","orcid":""}],"concentration_method":null,"concentration_unit":null,"date":"2024-05-09","storage_temperature":4.0,"cell_temperature":4.0,"exposure_time":600.0,"number_of_frames":6,"wavelength":0.154,"sample_detector_distance":4.955,"concentration_min":null,"concentration_max":0.6,"sample_volume":null,"flow_rate":null,"s_min":0.034,"s_max":6.106,"total_exposure_time":null,"seccolumn":null},"fits":[{"models":[{"model_plot":"https://www.sasbdb.org/media/pdb_file/images/SASDXV3_fit1_model1_img.png","software":"AlphaFold","pdb_link":[],"model_title":null,"type_of_model":"atomic","software_version":null,"model_data":"https://www.sasbdb.org/media/pdb_file/SASDXV3_fit1_model1.pdb","model_mw":93.05,"bead_radius":null,"log":null,"symmetry":null,"comment":null,"user":1001}],"fit_unit":"1/A","fit_plot":"https://www.sasbdb.org/media/fitting_files/scattering_plots/SASDXV3_fit1_fixed_fit_img.png","software":"FoXS","chi_square_value":1.939,"p_value":0.0001,"fit_residual_plot":"SASDXV3_fit1_fitresiduals_img.png","fit_data":"https://www.sasbdb.org/media/fitting_files/SASDXV3_fit1.fit","fit_log":null,"software_version":null,"description":""}],"estimated_volume_method":null,"pddf_software":"ATSAS GNOM","pddf_software_version":null,"i0_calibration_standard":null,"description":"Chenodeoxycholic acid (CDCA): https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL240597","experiment_description":"SAXS data from solutions of farnesoid X receptor homo-dimer bound to inverted repeat DNA in 50 mM HEPES, 150 mM NaCl, 5 % glycerol, 1 mM DTT, 20 µM CDCA, pH 7.4 were collected on a Rigaku BioSAXS-2000 instrument (Pennsylvania State University, University Park, PA, USA) using a Rigaku HyPix-3000 detector at a sample-detector distance of 5.0 m and at a wavelength of λ = 0.154 nm (I(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle). One solute concentration of 0.60 mg/ml was measured at 4°C. Six successive 600 second frames were collected. The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted.","tags":[],"intensity_unit":"arbitrary","experimental_mw":94.7,"experimental_mw_error":null,"guinier_i0_mw":null,"guinier_i0_mw_error":null,"porod_mw":null,"porod_mw_error":null,"pddf_i0":6.051,"pddf_i0_error":null,"guinier_i0":5.74754,"guinier_i0_error":null,"pddf_rg":5.83,"pddf_rg_error":null,"guinier_rg":5.05,"guinier_rg_error":0.078,"pddf_dmax":23.2,"pddf_dmax_error":null,"porod_volume":120.0,"porod_volume_error":null,"estimated_volume":null,"estimated_volume_error":null,"guinier_point_first":9,"guinier_point_last":28,"pddf_point_first":null,"pddf_point_last":null,"i0_calibration_standard_data":null,"intensities_log_log_plot":"SASDXV3_datloglog_img.png","symmetry":null,"last_modified":"2026-02-26T13:30:46.344061+01:00","bragg_peak":[]}