{"code":"SASDYX5","status":"Published","type_of_curve":"Merged","angular_unit":"1/A","project":{"title":"An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.","publication":{"title":"An intrinsically disordered region mediates RNA-binding selectivity and cellular activities of LARP6.","author_list":"Capraro F, Abis G, Incocciati A, Simpson PJ, Karimzadeh M, Masino L, Barley A, Bui TTT, Kelly G, Goodarzi H, Conte MR, Mardakheh FK","journal":"Nat Commun","doi":"10.1038/s41467-026-69789-z","pmid":"41714637","published_date":"2026 Feb 19"},"status":"released","submitted_date":"2026-01-20","released_date":"2026-02-21"},"pddf_data":"https://www.sasbdb.org/media/p_of_R_files/SASDYX5.dat","intensities_data":"https://www.sasbdb.org/media/intensities_files/SASDYX5.txt","intensities_log_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDYX5_dat_img.png","intensities_kratky_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDYX5_kratky_img.png","pddf_plot":"https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDYX5_pofr_img.png","intensities_guinier_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDYX5_guinier_img.png","sascif_data":"https://www.sasbdb.org/media/sascif/sascif_files/SASDYX5.sascif","experiment":{"instrument":{"detector":{"type":null,"name":"Eiger 4M","resolution":75.0},"name":"Diamond Light Source","city":"Didcot","country":"UK","beamline_name":"B21","beam_geometry":null,"type_of_source":"X-ray synchrotron","point_source":null,"line_collimation":null,"sample_path_length":null,"line_collimation_slitlength":null,"line_collimation_integrationwidth":null,"xray_energy":null,"beam_profile_ah":null,"beam_profile_al":null},"sample":{"molecule":[{"long_name":"La-related protein 6","short_name":"LARP6","sequence":"MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNENLPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKP","organism":"Homo sapiens","uniprot_code":"Q9BRS8","uniprot_range_first":1,"uniprot_range_last":300,"oligomerization":"monomer","molecular_type":"protein","uniprot_sequence":"MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEE\nEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVR\nRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNEN\nLPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELP\nPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKP\nAKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNK\nLSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYS\nSDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRG\nFHGHERSRACV","mw":33.917,"total_mw":33.917,"number_molecules":1,"complex_state":false,"deuteration":null,"molecule_source":"biological","molecule_description":"LARP6 N-terminal domain (NTD), comprising the N-terminal flexible tail and the two structured domains La-motif and RNA-recognition motif."}],"buffer":{"name":"25 mM Tris-HCl, 100 mM KCl, 5 mM MgCl2, 1 mM DTT","concentration_unit":null,"comment":"SEC-SAXS buffer","additive":null,"concentration":null,"pka":null,"ph":7.5,"deuteration":null},"purity_method":null,"name":"La-related protein 6 (LARP6) N-terminal domain (NTD) apo","ext_coefficient":null,"contrast":null,"specific_vol":null,"dry_vol":null,"absorbption":null,"deuteration":null,"mixture":null},"contributor":[{"affiliation":[{"short_name":null,"address":"London, UK","full_name":"King's College London","webpage":"https://www.kcl.ac.uk"}],"contributor_name":"Giancarlo","contributor_surname":"Abis","orcid":""}],"concentration_method":null,"concentration_unit":null,"date":"2024-10-01","storage_temperature":4.0,"cell_temperature":15.0,"exposure_time":0.35,"number_of_frames":600,"wavelength":0.09537,"sample_detector_distance":3.6903,"concentration_min":3.5,"concentration_max":4.5,"sample_volume":null,"flow_rate":null,"s_min":0.092,"s_max":3.4,"total_exposure_time":null,"seccolumn":null},"fits":[],"estimated_volume_method":null,"pddf_software":"ScÅtter","pddf_software_version":null,"i0_calibration_standard":null,"description":"LARP6 N-terminal domain (NTD), residues 1-300, comprising the N-terminal flexible tail and the two structured domains La-motif and RNA-recognition motif.\r\nExperimental molecular weight was estimated by SEC-MALLS.","experiment_description":null,"tags":[],"intensity_unit":"1/cm","experimental_mw":45.2,"experimental_mw_error":null,"guinier_i0_mw":null,"guinier_i0_mw_error":null,"porod_mw":86.0,"porod_mw_error":null,"pddf_i0":0.2929647,"pddf_i0_error":null,"guinier_i0":0.0645035,"guinier_i0_error":null,"pddf_rg":3.59,"pddf_rg_error":null,"guinier_rg":3.585,"guinier_rg_error":0.016,"pddf_dmax":15.0,"pddf_dmax_error":null,"porod_volume":138.0,"porod_volume_error":null,"estimated_volume":null,"estimated_volume_error":null,"guinier_point_first":13,"guinier_point_last":310,"pddf_point_first":null,"pddf_point_last":null,"i0_calibration_standard_data":null,"intensities_log_log_plot":"SASDYX5_datloglog_img.png","symmetry":null,"last_modified":"2026-02-21T16:07:19.723959+01:00","bragg_peak":[]}