{"code":"SASDYY2","status":"Published","type_of_curve":"Extrapolated to infinite dilution","angular_unit":"1/nm","project":{"title":"Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy.","publication":{"title":"Atomistic scattering modelling of the solution structure of human dimeric IgA1 reveals a structural and mechanistic basis for IgA nephropathy.","author_list":"Bhatt JS, Yeo SC, Ireland SM, Ben-Younis A, Gor J, Molyneux K, Barratt J, Perkins SJ","journal":"J Biol Chem","doi":"10.1016/j.jbc.2026.113156","pmid":"42140437","published_date":"2026 May 14"},"status":"released","submitted_date":"2025-11-29","released_date":"2026-05-27"},"pddf_data":"https://www.sasbdb.org/media/p_of_R_files/SASDYY2.out","intensities_data":"https://www.sasbdb.org/media/intensities_files/SASDYY2.txt","intensities_log_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDYY2_dat_img.png","intensities_kratky_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDYY2_kratky_img.png","pddf_plot":"https://www.sasbdb.org/media/p_of_R_files/pofr_images/SASDYY2_pofr_img.png","intensities_guinier_plot":"https://www.sasbdb.org/media/intensities_files/scattering_plots/SASDYY2_guinier_img.png","sascif_data":"https://www.sasbdb.org/media/sascif/sascif_files/SASDYY2.sascif","experiment":{"instrument":{"detector":{"type":"Dectris","name":"Pilatus 1M","resolution":172.0},"name":"ESRF","city":"Grenoble","country":"France","beamline_name":"BM29","beam_geometry":"","type_of_source":"X-ray synchrotron","point_source":null,"line_collimation":null,"sample_path_length":null,"line_collimation_slitlength":null,"line_collimation_integrationwidth":null,"xray_energy":null,"beam_profile_ah":null,"beam_profile_al":null},"sample":{"molecule":[{"long_name":"Human immunoglobulin IgA1","short_name":"IgA1","sequence":">sp|Chains A,L,C,N|Immunoglobulin light chain|Homo sapiens\r\nDIVMTQSPLSLSVTPGEPASISCRSSQSLLRRDGHNDLEWYLQKPGQSPQPLIYLGSTRASGVPDRFSGSGSGTDFTLKIIRVEAEDAGTYYCMQNKQTPLTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC\r\n>sp|Chains B,M,D,O|Immunoglobulin heavy chain|Homo sapiens\r\nEVQLVESGGGLVQPGGSLKLSCAASGFTLSGSNVHWVRQASGKGLEWVGRIKRNAESDATAYAASMRGRLTISRDDSKNTAFLQMNSLKSDDTAMYYCVIRGDVYNRQWGQGTLVTVSSASPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESGQGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY\r\n>sp|Chain J|Immunoglobulin joining chain|Homo sapiens\r\nEDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDNQIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD","organism":null,"uniprot_code":null,"uniprot_range_first":null,"uniprot_range_last":null,"oligomerization":"dimer","molecular_type":"protein","uniprot_sequence":"","mw":160.0,"total_mw":320.0,"number_molecules":2,"complex_state":false,"deuteration":null,"molecule_source":"biological","molecule_description":""}],"buffer":{"name":"PBS buffer, 137 mM NaCl, 8.2 mM Na2HPO4, 2.6 mM KCl, 1.5 mM KH2PO4","concentration_unit":null,"comment":null,"additive":null,"concentration":null,"pka":null,"ph":7.4,"deuteration":null},"purity_method":null,"name":"IgA1 dimer - Patient B","ext_coefficient":null,"contrast":null,"specific_vol":null,"dry_vol":null,"absorbption":null,"deuteration":null,"mixture":null},"contributor":[{"affiliation":[{"short_name":null,"address":"London, UK","full_name":"University College London","webpage":"https://www.ucl.ac.uk/"}],"contributor_name":"Jayesh","contributor_surname":"Bhatt","orcid":"https://orcid.org/0000-0001-9265-755X"}],"concentration_method":null,"concentration_unit":null,"date":"2014-09-07","storage_temperature":20.0,"cell_temperature":20.0,"exposure_time":1.0,"number_of_frames":10,"wavelength":0.09919,"sample_detector_distance":2.867,"concentration_min":0.33,"concentration_max":1.31,"sample_volume":null,"flow_rate":null,"s_min":0.104,"s_max":1.502,"total_exposure_time":null,"seccolumn":null},"fits":[{"models":[{"model_plot":"https://www.sasbdb.org/media/pdb_file/images/SASDYY2_fit1_model1_img.png","software":"Custom in-house","pdb_link":[],"model_title":null,"type_of_model":"mix","software_version":null,"model_data":"https://www.sasbdb.org/media/pdb_file/SASDYY2_fit1_model1.pdb","model_mw":307.5,"bead_radius":1.9,"log":null,"symmetry":null,"comment":null,"user":1285}],"fit_unit":"1/nm","fit_plot":"https://www.sasbdb.org/media/fitting_files/scattering_plots/SASDYY2_fit1_fixed_fit_img.png","software":"Other","chi_square_value":null,"p_value":0.0,"fit_residual_plot":"fit4columns8688_fitresiduals_img.png","fit_data":"https://www.sasbdb.org/media/fitting_files/SASDYY2_fit1.fit","fit_log":null,"software_version":"SASSIE-web","description":"Curve fitting was performed using the online SASSIE-web portal: \r\n\r\nhttps://sassie-web.chem.utk.edu/sassie2/\r\n\r\nThe workflow for this atomistic modelling is described in: \r\nPerkins et al., (2016) J. Appl. Cryst. 49(6), 1861-1875. \r\n\r\nThe modelled scattering curve was obtained using the 'golden vector' method, implemented in the SasCalc module in SASSIE-web, and described in: \r\nWatson and Curtis, (2013) J. Appl. Cryst. 46, 1171-1177."}],"estimated_volume_method":null,"pddf_software":"ATSAS GNOM","pddf_software_version":"4.6","i0_calibration_standard":null,"description":"CAUTION: Errors associated with the scattering data points are not available.","experiment_description":null,"tags":[],"intensity_unit":"arbitrary","experimental_mw":317.0,"experimental_mw_error":null,"guinier_i0_mw":null,"guinier_i0_mw_error":null,"porod_mw":null,"porod_mw_error":null,"pddf_i0":1.037,"pddf_i0_error":null,"guinier_i0":1.0,"guinier_i0_error":null,"pddf_rg":9.15,"pddf_rg_error":null,"guinier_rg":8.407,"guinier_rg_error":0.043,"pddf_dmax":35.0,"pddf_dmax_error":null,"porod_volume":null,"porod_volume_error":null,"estimated_volume":null,"estimated_volume_error":null,"guinier_point_first":1,"guinier_point_last":15,"pddf_point_first":null,"pddf_point_last":null,"i0_calibration_standard_data":null,"intensities_log_log_plot":"SASDYY2_datloglog_img.png","symmetry":null,"last_modified":"2026-05-27T14:18:49.364533+02:00","bragg_peak":[]}