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6 hits found for Muñoz

SASDVB5 – CCDC6-RET fusion protein variant c

CCDC6-RET fusion protein variant c (K147M, Δ216-229) experimental SAS data
DAMMIN model
Sample: CCDC6-RET fusion protein variant c (K147M, Δ216-229) dimer, 86 kDa Homo sapiens protein
Buffer: 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Sep 18
The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase Nature Communications (2026)
...Muñoz I, Gago F, Muñoz J, Isasa M, Plaza-Menacho I
RgGuinier 5.5 nm
Dmax 19.5 nm
VolumePorod 260 nm3

SASDWN5 – N-acetylmuramoyl-L-alanine amidase (without His-Tag)

N-acetylmuramoyl-L-alanine amidase experimental SAS data
COOT model
Sample: N-acetylmuramoyl-L-alanine amidase monomer, 43 kDa Mycobacterium phage DS6A protein
Buffer: 20 mM Tris, 150 mM NaCl and 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Sep 30
Dissecting the molecular basis underlying mycobacterial cell-wall hydrolysis by the catalytic domains of D29LysA and DS6ALysA phage endolysins. Int J Biol Macromol :148896 (2025)
...Muñoz IG, Infantes L, Fernández-Carrillo J, Pérez-Dorado I
RgGuinier 2.8 nm
Dmax 9.5 nm
VolumePorod 50 nm3

SASDWP5 – N-acetylmuramoyl-L-alanine amidase (with His-Tag)

N-acetylmuramoyl-L-alanine amidase (Mycobacteriophage DS6A) experimental SAS data
COOT model
Sample: N-acetylmuramoyl-L-alanine amidase (Mycobacteriophage DS6A) monomer, 45 kDa protein
Buffer: 20 mM Tris, 150 mM NaCl and 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Mar 30
Dissecting the molecular basis underlying mycobacterial cell-wall hydrolysis by the catalytic domains of D29LysA and DS6ALysA phage endolysins. Int J Biol Macromol :148896 (2025)
...Muñoz IG, Infantes L, Fernández-Carrillo J, Pérez-Dorado I
RgGuinier 2.8 nm
Dmax 10.3 nm
VolumePorod 62 nm3

SASDSV8 – Tyrosine-protein kinase Src (c-Src WT)

Proto-oncogene tyrosine-protein kinase Src experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Proto-oncogene tyrosine-protein kinase Src monomer, 52 kDa Homo sapiens protein
Buffer: 20 mM Tris pH 8.0, 150 mM NaCl, 1% glycerol and 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 May 8
An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function Nature Communications 14(1) (2023)
...Muñoz I, Kannan N, Llimargas M, Muñoz J, Plaza-Menacho I
RgGuinier 2.6 nm
Dmax 8.9 nm
VolumePorod 67 nm3

SASDWT6 – Frataxin bound to tailored nanobody 16C10

Frataxin, mitochondrialNanobody 16C10 experimental SAS data
COOT model
Sample: Frataxin, mitochondrial monomer, 14 kDa Homo sapiens protein
Nanobody 16C10 monomer, 15 kDa synthetic construct protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Sep 18
Nanobodies as tools for studying human frataxin biology. Commun Biol (2026)
...Muñoz IG, Grossi J, Noguera M, Vila A, García AE, Gentili HG, Rodríguez NA, Aran M, Parreño V, Bok M, Hermoso JA, Ibañez LI, Santos J
RgGuinier 2.4 nm
Dmax 8.0 nm
VolumePorod 37 nm3

SASDWS6 – Frataxin bound to tailored nanobody 28F6

Frataxin, mitochondrialNanobody 28F6 experimental SAS data
ALPHAFOLD model
Sample: Frataxin, mitochondrial monomer, 14 kDa Homo sapiens protein
Nanobody 28F6 monomer, 15 kDa synthetic construct protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2024 Sep 18
Nanobodies as tools for studying human frataxin biology. Commun Biol (2026)
...Muñoz IG, Grossi J, Noguera M, Vila A, García AE, Gentili HG, Rodríguez NA, Aran M, Parreño V, Bok M, Hermoso JA, Ibañez LI, Santos J
RgGuinier 2.2 nm
Dmax 7.4 nm
VolumePorod 36 nm3