Structural basis of hepatocyte growth factor/scatter factor and MET signalling

Gherardi E, Sandin S, Petoukhov M, Finch J, Youles M, Ofverstedt L, Miguel R, Blundell T, Vande Woude G, Skoglund U, Svergun D
Proceedings of the National Academy of Sciences 103(11):4046-4051 (2006 Mar 06)

doi: 10.1073/pnas.0509040103 		Submitted to SASBDB: 2021 Jun 25
Published in SASBDB:

SASDLP7 – Two-chain hepatocyte growth factor/scatter factor in complex with receptor tyrosine kinase MET

Hepatocyte growth factorHepatocyte growth factor receptor experimental SAS data
SASREF model
Sample: Hepatocyte growth factor monomer, 79 kDa Mus musculus protein
Hepatocyte growth factor receptor monomer, 100 kDa Mus musculus protein
Buffer: 50 mM MES, 150 mM NaCl, pH: 6.7
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2004 Feb 9
RgGuinier 6.7 nm
Dmax 20.0 nm
VolumePorod 370 nm3

SASDLQ7 – receptor tyrosine kinase MET

Hepatocyte growth factor receptor experimental SAS data
SASREF model
Sample: Hepatocyte growth factor receptor monomer, 100 kDa Mus musculus protein
Buffer: 50 mM MES, 150 mM NaCl, pH: 6.7
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2004 Feb 7
RgGuinier 4.8 nm
Dmax 16.0 nm
VolumePorod 190 nm3