Engineering the NK1 Fragment of Hepatocyte Growth Factor/Scatter Factor as a MET Receptor Antagonist

Youles M, Holmes O, Petoukhov M, Nessen M, Stivala S, Svergun D, Gherardi E
Journal of Molecular Biology 377(3):616-622 (2008 Mar)

doi: 10.1016/j.jmb.2008.01.034 		Submitted to SASBDB: 2021 May 26
Published in SASBDB:

SASDLZ5 – Hepatocyte growth factor/Hepatocyte growth factor receptor (NK1-Met567) complex

Hepatocyte growth factorHepatocyte growth factor receptor experimental SAS data
MONSA model
Sample: Hepatocyte growth factor dimer, 39 kDa Homo sapiens protein
Hepatocyte growth factor receptor dimer, 122 kDa Homo sapiens protein
Buffer: Phosphate-buffered saline containing EDTA, surfactant P20 and 5 M NaCl, pH: 6
Experiment: SAXS data collected at EMBL X33, DORIS III, DESY on 2007 Jun 26
RgGuinier 5.3 nm
Dmax 20.0 nm
VolumePorod 290 nm3