| MWexperimental | 430 | kDa |
| MWexpected | 16740 | kDa |
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log I(s)
6.98×101
6.98×100
6.98×10-1
6.98×10-2
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s, nm-1
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Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system.
Filippov SK, Chytil P, Konarev PV, Dyakonova M, Papadakis C, Zhigunov A, Plestil J, Stepanek P, Etrych T, Ulbrich K, Svergun DI, Biomacromolecules 13(8):2594-604 (2012) Europe PMCSASDMS2 – HPMA-Based Nanoparticles with Cholesterol (2.7%)
N-(2-hydroxypropyl)- 31 methacrylamide (HPMA) copolymers with Cholesterol (2.7%)|
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Fits and models
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Synchrotron SAXS
data from solutions of
HPMA-Based Nanoparticles with Cholesterol (2.7%)
in
phosphate buffer saline (PBS) (pH 7.2), pH 7.2
were collected
on the
EMBL X33 beam line
at the DORIS III, DESY storage ring
(Hamburg, Germany)
using a Pilatus 1M-W detector
at a sample-detector distance of 2.7 m and
at a wavelength of λ = 0.154 nm
(I(s) vs s, where s = 4πsinθ/λ, and 2θ is the scattering angle).
One solute concentration of 2.00 mg/ml was measured
at 20°C.
Eight successive
15 second frames were collected.
The data were normalized to the intensity of the transmitted beam and radially averaged; the scattering of the solvent-blank was subtracted.
Tags:
X33
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