Tri-specific antibody

UCB0159 protein

Organism: Homo sapiens

Monomeric molecular weight: 102.3 kDa

Oligomeric state: Monomer

Total molecular weight: 102.3 kDa

Sequence:

AIQLTQSPSSLSASVGDRVTITCRADESVRTLMHWYQQKPGKAPKLLIYLVSNSEIGVPDRFSGSGSGTD FRLTISSLQPEDFATYYCQQTWSDPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFY PREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLTKDEYEKHKVYACEVTHQGLSSPVTKSFNRGECSGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAVSGIDLSNYAINWVRQAPGKCLEWIGIIWASGTTFYATWAKGRFTISRDNSKNTVYLQMNSLRAEDTAVYYCARTVPGYSTAPYFDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSVSASVGDRVTITCQSSPSVWSNFLSWYQQKPGKAPKLLIYEASKLTSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCGGGYSSISDTTFGCGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYNMAWVRQAPGKGLEWVATITYEGRNTYYRDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCASPPQYYEGSIYRLWFAHWGQGTLVTVSSASTKGPSVFPLAPSSSKSTSGGTTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCSGGGGSGGGGGSEVQLVESGGGLVKPGGSLRLSCAASGYTFTDNYIHWVRQAPGKGLEWIGYINPSSAYAHYNEKFKTRFTISVDKAKNSAYLQMNSLRAEDTAVYYCTRRYYSAMPFAYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASEDIYSGLAWYQQKPGKVPKLLIYDSSTLHTGVPSRFSGTGSGTDYTLTISSLQPEDVATYFCQQNYDFPLTFGQGTKLEIKRT

A Tri-specific antibody therapeutic consisting of an anti-IL-17 A/F Fragment antigen binding (Fab) with an anti-TNF single chain fragment variable (scFv) attached to the the light chain and an anti-albumin scFv attached to the heavy chain by G4S linker's.