SASDL82 – Human acetylcholinesterase, apo

acetylcholinesteraseacetylcholinesterase experimental SAS data
OTHER model
Sample: acetylcholinesterase dimer, 120 kDa Homo sapiens protein
acetylcholinesterase monomer, 60 kDa Homo sapiens protein
Buffer: 50 mM Tris/HCl, 100 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BL4-2, Stanford Synchrotron Radiation Lightsource (SSRL) on 2015 May 29
Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
Donald Blumenthal
RgGuinier 3.9 nm
Dmax 13.0 nm
VolumePorod 162 nm3

SASDL92 – Human acetylcholinesterase, covalently bound to paraoxon

acetylcholinesteraseacetylcholinesterase experimental SAS data
PDB model
Sample: acetylcholinesterase dimer, 120 kDa Homo sapiens protein
acetylcholinesterase monomer, 60 kDa Homo sapiens protein
Buffer: 50 mM Tris/HCl, 100 mM NaCl, pH: 7.4
Experiment: SAXS data collected at BL4-2, Stanford Synchrotron Radiation Lightsource (SSRL) on 2015 May 29
Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects
Donald Blumenthal
RgGuinier 3.4 nm
Dmax 12.0 nm
VolumePorod 142 nm3

SASDLZ2 – Immunoglobulin G3 (IgG3) Glycosylated

Immunoglobulin G subclass 3 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 3 monomer, 155 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Jul 29
Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses. J Biol Chem :100995 (2021)
Spiteri VA, Goodall M, Doutch J, Rambo RP, Gor J, Perkins SJ
RgGuinier 7.0 nm
Dmax 22.9 nm
VolumePorod 267 nm3

SASDL23 – Immunoglobulin G3 (IgG3) Deglycosylated

Immunoglobulin G subclass 3 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 3 monomer, 155 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Jul 29
Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses. J Biol Chem :100995 (2021)
Spiteri VA, Goodall M, Doutch J, Rambo RP, Gor J, Perkins SJ
RgGuinier 7.1 nm
Dmax 27.7 nm
VolumePorod 294 nm3

SASDGG6 – Ubiquitin activating enzyme 5 (0.3 mg/ml)

Ubiquitin-like modifier-activating enzyme 5 experimental SAS data
SASREF model
Sample: Ubiquitin-like modifier-activating enzyme 5 dimer, 68 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 2 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Jun 13
Cooperativity of UBA5-UFM1 complex formation
Sebastian Fuchs
RgGuinier 2.8 nm
Dmax 9.0 nm
VolumePorod 74 nm3

SASDGH6 – Ubiquitin activating enzyme 5 (1.0 mg/ml)

Ubiquitin-like modifier-activating enzyme 5 experimental SAS data
SASREF model
Sample: Ubiquitin-like modifier-activating enzyme 5 dimer, 68 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 2 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Jun 13
Cooperativity of UBA5-UFM1 complex formation
Sebastian Fuchs
RgGuinier 2.9 nm
Dmax 10.0 nm
VolumePorod 82 nm3

SASDGJ6 – Ubiquitin activating enzyme 5 (6.8 mg/ml)

Ubiquitin-like modifier-activating enzyme 5 experimental SAS data
SASREF model
Sample: Ubiquitin-like modifier-activating enzyme 5 dimer, 68 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 2 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Jun 13
Cooperativity of UBA5-UFM1 complex formation
Sebastian Fuchs
RgGuinier 3.2 nm
Dmax 12.0 nm
VolumePorod 108 nm3

SASDGK6 – Ubiquitin activating enzyme 5 (4.4 mg/ml)

Ubiquitin-like modifier-activating enzyme 5 experimental SAS data
SASREF model
Sample: Ubiquitin-like modifier-activating enzyme 5 dimer, 68 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 2 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Jun 13
Cooperativity of UBA5-UFM1 complex formation
Sebastian Fuchs
RgGuinier 3.1 nm
Dmax 12.0 nm
VolumePorod 104 nm3

SASDGL6 – Ubiquitin activating enzyme 5 (3.6 mg/ml)

Ubiquitin-like modifier-activating enzyme 5 experimental SAS data
SASREF model
Sample: Ubiquitin-like modifier-activating enzyme 5 dimer, 68 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 2 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Jun 13
Cooperativity of UBA5-UFM1 complex formation
Sebastian Fuchs
RgGuinier 3.0 nm
Dmax 11.0 nm
VolumePorod 97 nm3

SASDGM6 – Ubiquitin activating enzyme 5 (1.9 mg/ml)

Ubiquitin-like modifier-activating enzyme 5 experimental SAS data
SASREF model
Sample: Ubiquitin-like modifier-activating enzyme 5 dimer, 68 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM NaCl, 2 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Jun 13
Cooperativity of UBA5-UFM1 complex formation
Sebastian Fuchs
RgGuinier 2.9 nm
Dmax 9.8 nm
VolumePorod 94 nm3

2118 hits found.