Curated repository for small angle scattering data and models


SASBDB currently contains:


2828

experimental data sets

3998

models
550 experimental data sets on hold
660 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDNX3 – Calcium-bound Calmodulin, including structural models

Calmodulin-1 experimental SAS data
Calcium-bound Calmodulin, including structural models Rg histogram
Sample: Calmodulin-1 monomer, 17 kDa Homo sapiens protein
Buffer: 20 mM Hepes, 150 mM NaCl, 2 mM CaCl2, pH: 7.4
Experiment: SAXS data collected at SWING, SOLEIL on 2020 Nov 15
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium. BMC Biol 20(1):176 (2022)
Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A
RgGuinier 2.2 nm
Dmax 7.2 nm
VolumePorod 33 nm3

Mycobacterium phage TipsytheTRex immunity repressor bound to 24mer DNA
Immunity repressor24mer dsDNA experimental SAS data
A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence. Nat Commun 2022 Jul 14;13(1):4105
Nat Commun 13(1):4105 (2022 Jul 14)
Nuclear factor kB p50/RelA heterodimer
Transcription factor p65 19-549NF-kappa-B p105 subunit 39-350 experimental SAS data
An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA. J Biol Chem 2022 Aug 4;:102349
J Biol Chem :102349 (2022 Aug 4)
Arabidopsis thaliana beta-amylase 1
Beta-amylase 1, chloroplastic experimental SAS data
The BAM7 gene in Zea mays encodes a protein with similar structural and catalytic properties to Arabidopsis BAM2 Acta Crystallographica Section D Structural Biology 2022 Apr 08 78(5)
Acta Crystallographica Section D Structural Biology 78(5) (2022 Apr 08)
DPCD His-RuvBl1/RuvBl2 hexamer complex
Protein DPCDRuvB-like 1RuvB-like 2 experimental SAS data
Deciphering cellular and molecular determinants of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases. J Mol Biol 2022 Jul 25;:167760
J Mol Biol :167760 (2022 Jul 25)
Hepatocyte growth factor HGF/SF receptor - fragment MET567 in complex with the minimal hepatocyte growth factor mimic K1K1
minimal hepatocyte growth factor mimic K1K1Hepatocyte growth factor receptor experimental SAS data
Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist Life Science Alliance 2022 Jul 29 5(12):e202201424
Life Science Alliance 5(12):e202201424 (2022 Jul 29)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.