Curated repository for small angle scattering data and models


SASBDB currently contains:


4101

experimental data sets

5470

models
549 experimental data sets on hold
527 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDTA5 – Trypanosoma brucei gambiense variable surface glycoprotein LiTat 1.5

Variable surface glycoprotein LiTat 1.5 experimental SAS data
BILBOMD model
Sample: Variable surface glycoprotein LiTat 1.5 dimer, 98 kDa Trypanosoma brucei gambiense protein
Buffer: 50 mM Tris-HCl, 500 mM NaCl, pH: 7.5
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Sep 8
Beyond the VSG Layer: Exploring the Role of Intrinsic Disorder in the Invariant Surface Glycoproteins of African Trypanosomes. PLoS Pathog 20(4):e1012186 (2024)
Sülzen H, Volkov AN, Geens R, Zahedifard F, Stijlemans B, Zoltner M, Magez S, Sterckx YG, Zoll S
RgGuinier 4.4 nm
Dmax 17.2 nm
VolumePorod 170 nm3

Nucleotide binding domain, NBD (ABC transporter domain) from the RTX toxin ABC transporter RtxB
RTX toxin transporter experimental SAS data
Type 1 secretion necessitates a tight interplay between all domains of the ABC transporter Scientific Reports 2024 Apr 18 14(1)
Scientific Reports 14(1) (2024 Apr 18)
TIP120 (designed based on Truncated Icosahedral Protein composed of 60-mer fusion proteins)
N-terminal split fragment of a single subunit of Truncated Icosahedral Protein composed of 60-mer fusion proteinsC-terminal split fragment of a single subunit of Truncated Isosahedral Protein composed of 60-mer fusion proteins experimental SAS data
Fusion then fission: splitting and reassembly of an artificial fusion-protein nanocage. Chem Commun (Camb) 2024 Apr 8;
Chem Commun (Camb) (2024 Apr 8)
Threonine aldolase 1 tetramer at neutral pH
L-threonine aldolase experimental SAS data
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse. Nat Commun 2024 Apr 13;15(1):3199
Nat Commun 15(1):3199 (2024 Apr 13)
Ubiquitin-specific protease 14 (USP14)
Ubiquitin carboxyl-terminal hydrolase 14 experimental SAS data
Transient interdomain interactions in free USP14 shape its conformational ensemble. Protein Sci 2024 May;33(5):e4975
Protein Sci 33(5):e4975 (2024 May)
Immunoglobulin G4 (IgG4) Glycosylated
Immunoglobulin G subclass 4 experimental SAS data
Using atomistic solution scattering modelling to elucidate the role of the Fc glycans in human IgG4. PLoS One 2024;19(4):e0300964
PLoS One 19(4):e0300964 (2024)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.