Curated repository for small angle scattering data and models


SASBDB currently contains:


2072

experimental data sets

3107

models
528 experimental data sets on hold
557 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDLU3 – Human Albumin (C1)

Albumin experimental SAS data
SREFLEX model
Sample: Albumin monomer, 69 kDa Homo sapiens protein
Buffer: 20 mM Tris, 150 mM KCl, 2% glycerol, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2020 Dec 1
Albumin in patients with liver disease shows an altered conformation. Commun Biol 4(1):731 (2021)
Paar M, Fengler VH, Rosenberg DJ, Krebs A, Stauber RE, Oettl K, Hammel M
RgGuinier 2.7 nm
Dmax 8.2 nm

Methylamine-treated alpha-2-macroglobulin, deglcycosylated
Alpha-2-macroglobulin experimental SAS data
Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism. Mol Cell Proteomics 2021 May 6;20:100090
Mol Cell Proteomics 20:100090 (2021 May 6)
Histidine kinase AdeS - DHp-CA Domain
Histidine kinase experimental SAS data
Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS. iScience 2021 May 21;24(5):102476
iScience 24(5):102476 (2021 May 21)
Sarcomeric F-actin crosslinking protein α-actinin-2 (spectrin repeat rod domain, rod-α-actinin-2)
Rod domain of α-actinin-2 experimental SAS data
Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin. Sci Adv 2021 May;7(22)
Sci Adv 7(22) (2021 May)
The truncated RTX domain of adenylate cyclase toxin CyaA - construct RTX-1 (amino acids 1132-1294 and 1562-1681 of CyaA)
hybrid RTX-1 construct (amino acids 1132-1294 and 1562-1681 of CyaA) experimental SAS data
Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the adenylate cyclase toxin. J Biol Chem 2021 May 26;:100833
J Biol Chem :100833 (2021 May 26)
SAXS data for the complex of the sensory rhodopsin II with its cognate truncated transducer in detergent at 0.15 M NaCl
Sensory rhodopsin II from Natronbacterium pharaonisTruncated sensory rhodopsin II transducer containing transmembrane and HAMP1 domains experimental SAS data
Molecular model of a sensor of two-component signaling system Scientific Reports 2021 May 24 11(1)
Scientific Reports 11(1) (2021 May 24)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.