Curated repository for small angle scattering data and models


SASBDB currently contains:


2544

experimental data sets

3654

models
477 experimental data sets on hold
557 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDMU7 – Apt31 - ssDNA aptamer specific to the receptor-binding domain of SARS-CoV-2

ssDNA aptamer Apt31 specific to the receptor-binding domain of SARS-CoV-2 experimental SAS data
GROMACS model
Sample: SsDNA aptamer Apt31 specific to the receptor-binding domain of SARS-CoV-2 monomer, 10 kDa Artificially synthesized DNA
Buffer: Tris-HCl, pH: 7.4
Experiment: SAXS data collected at 13A, Taiwan Photon Source on 2020 Dec 18
Structure and Interaction Based Design of Anti‐SARS‐CoV‐2 Aptamers Chemistry – A European Journal (2022)
Mironov V, Shchugoreva I, Artyushenko P, Morozov D, Borbone N, Oliviero G, Zamay T, Moryachkov R, Kolovskaya O, Lukyanenko K, Song Y, Merkuleva I, Zabluda V, Peters G, Koroleva L, Veprintsev D, Glazyrin Y, Volosnikova E, Belenkaya S, Esina T, Isaeva A, Nesmeyanova V, Shanshin D, Berlina A, Komova N, Svetlichnyi V, Silnikov V, Shcherbakov D, Zamay G, Zamay S, Smolyarova T, Tikhonova E, Chen K, Jeng U, Condorelli G, de Franciscis V, Groenhof G, Yang C, Moskovsky A, Fedorov D, Tomilin F, Tan W, Alexeev Y, Berezovski M, Kichkailo A
RgGuinier 1.9 nm
Dmax 6.5 nm
VolumePorod 12 nm3

SANS data from cytochrome c' from Alcaligenes xylosoxidans at pD = 9.6
Cytochrome c' experimental SAS data
Cytochrome c' Kratky plot
Open-Bundle Structure as the Unfolding Intermediate of Cytochrome c′ Revealed by Small Angle Neutron Scattering Biomolecules 2022 Jan 07 12(1):95
Biomolecules 12(1):95 (2022 Jan 07)
Non-POU domain-containing octamer-binding protein (NONO homodimer) bound to an antisense oligonucleotide
Non-POU domain-containing octamer-binding protein5-10-5 gapmer phosphorothioate antisense oligonucleotide tetramer experimental SAS data
Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1. Nucleic Acids Res 2021 Dec 14;
Nucleic Acids Res (2021 Dec 14)
HOLO-serotransferrin at pH 8.0 in the presence of iron
Serotransferrin experimental SAS data
X-ray Characterization of Conformational Changes of Human Apo- and Holo-Transferrin International Journal of Molecular Sciences 2021 Dec 13 22(24):13392
International Journal of Molecular Sciences 22(24):13392 (2021 Dec 13)
Mouse Kirrel3 ectodomain
Kin of IRRE-like protein 3 experimental SAS data
Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep 2021 Nov 2;37(5):109940
Cell Rep 37(5):109940 (2021 Nov 2)
2:1 complex between anti prion protein monoclonal IgG 6D11 and recombinant murine prion protein
Major prion proteinAnti-prion protein monoclonal IgG2a 6D11 experimental SAS data
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies. Sci Adv 2021 Nov 26;7(48):eabj1826
Sci Adv 7(48):eabj1826 (2021 Nov 26)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.