Curated repository for small angle scattering data and models


SASBDB currently contains:


2118

experimental data sets

3195

models
549 experimental data sets on hold
594 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDLZ2 – Immunoglobulin G3 (IgG3) Glycosylated

Immunoglobulin G subclass 3 experimental SAS data
CUSTOM IN-HOUSE model
Sample: Immunoglobulin G subclass 3 monomer, 155 kDa Homo sapiens protein
Buffer: 20 mM L-histidine, 138 mM NaCl, and 2.6 mM KCl buffer, pH: 6
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Jul 29
Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses. J Biol Chem :100995 (2021)
Spiteri VA, Goodall M, Doutch J, Rambo RP, Gor J, Perkins SJ
RgGuinier 7.0 nm
Dmax 22.9 nm
VolumePorod 267 nm3

Wild-type human myelin protein P2
Myelin P2 protein experimental SAS data
Human myelin protein P2: from crystallography to time-lapse membrane imaging and neuropathy-associated variants. FEBS J 2021 Jun 17;
FEBS J (2021 Jun 17)
E2F1/DP1 in complex with a 15-mer DNA oligo
Transcription factor E2F115-mer DNA oligo of the human E2F1 promoterE2F dimerization partner 1 experimental SAS data
High Conformational Flexibility of the E2F1/DP1/DNA Complex. J Mol Biol 2021 Jun 25;433(18):167119
J Mol Biol 433(18):167119 (2021 Jun 25)
Ectodomain of human syndecan-1
Syndecan-1 experimental SAS data
Extended disorder at the cell surface: the conformational landscape of the ectodomains of syndecans Matrix Biology Plus 2021 Jul :100081
Matrix Biology Plus :100081 (2021 Jul)
Dephosphorylated tyrosyl-DNA phosphodiesterase 1 (TDP1-Ppi)
Tyrosyl-DNA phosphodiesterase 1 (dephosphorylated) experimental SAS data
Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. J Biol Chem 2021 Jun 25;:100921
J Biol Chem :100921 (2021 Jun 25)
Human Albumin (C1)
Albumin experimental SAS data
Albumin in patients with liver disease shows an altered conformation. Commun Biol 2021 Jun 14;4(1):731
Commun Biol 4(1):731 (2021 Jun 14)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.