Curated repository for small angle scattering data and models


SASBDB currently contains:


1552

experimental data sets

2378

models
429 experimental data sets on hold
427 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDHN8 – Human tumor necrosis factor receptor superfamily member 5 (CD40) extracellular domain in complex with human immunoglobulin gamma 1 (IgG1) 341G2 F(ab)

Tumor necrosis factor receptor superfamily member 5Human 341G2 F(ab) experimental SAS data
HADDOCK model
Sample: Tumor necrosis factor receptor superfamily member 5 monomer, 19 kDa Homo sapiens protein
Human 341G2 F(ab) monomer, 73 kDa Homo sapiens protein
Buffer: Phosphate-buffered saline, pH: 7
Experiment: SAXS data collected at B21, Diamond Light Source on 2019 Sep 18
Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity Cancer Cell (2020)
Yu X, Chan H, Fisher H, Penfold C, Kim J, Inzhelevskaya T, Mockridge C, French R, Duriez P, Douglas L, English V, Verbeek J, White A, Tews I, Glennie M, Cragg M
RgGuinier 3.7 nm
Dmax 13.4 nm
VolumePorod 97 nm3

1:2 heterotrimer of pUL7 and pUL51(8-142) from herpes simplex virus 1
Tegument protein UL7Tegument protein UL51 experimental SAS data
Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex. Elife 2020 May 11;9
Elife 9 (2020 May 11)
Bruton's Tyrosine Kinase - SH3-SH2-kinase domain
Bruton's tyrosine kinase - Src homology 3-2 kinase domain experimental SAS data
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms Nature Communications 2020 May 8 11(1)
Nature Communications 11(1) (2020 May 8)
Meiotic localizer of BRCA2 bound to BRME1 - MEILB2a1+2-BRME1 2:2 complex
BRME1Meiotic localizer of BRCA2 experimental SAS data
The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells Nature Communications 2020 Apr 28 11(1)
Nature Communications 11(1) (2020 Apr 28)
Interleukin 11 receptor subunit alpha
Interleukin-11 receptor subunit alpha experimental SAS data
The structure of the extracellular domains of human interleukin 11 α-receptor reveals mechanisms of cytokine engagement Journal of Biological Chemistry 2020 Apr 24 :jbc.RA119.012351
Journal of Biological Chemistry :jbc.RA119.012351 (2020 Apr 24)
Ile-Leu-Gln-Ile-Asn-Ser (ILQINS) hexapeptide self-assembly
Ile-Leu-Gln-Ile-Asn-Ser peptide experimental SAS data
Amyloid Evolution: Antiparallel Replaced by Parallel. Biophys J 2020 Apr 7;
Biophys J (2020 Apr 7)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated andvalidated repository for biological scattering data. Protein Science 29(1); 66-75.