Curated repository for small angle scattering data and models


SASBDB currently contains:


4394

experimental data sets

5729

models
594 experimental data sets on hold
716 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDVH7 – Third double-stranded RNA-binding domain of Human Double-stranded RNA-specific adenosine deaminase (ADAR1) (residues 716-797, i.e. dsRBD3-short)

Third double-stranded RNA-binding domain of human ADAR1 (residues 716-797, i.e. dsRBD3-short) experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Third double-stranded RNA-binding domain of human ADAR1 (residues 716-797, i.e. dsRBD3-short) dimer, 18 kDa Homo sapiens protein
Buffer: 20 mM Na-HEPES, 55 mM KOAc, 10 mM NaCl, 1 mM TCEP, pH: 7.3
Experiment: SAXS data collected at SWING, SOLEIL on 2020 Jun 27
Dimerization of ADAR1 modulates site-specificity of RNA editing Nature Communications 15(1) (2024)
Mboukou A, Rajendra V, Messmer S, Mandl T, Catala M, Tisné C, Jantsch M, Barraud P
RgGuinier 1.9 nm
Dmax 5.5 nm
VolumePorod 27 nm3

Staphylococcus aureus Fatty Acid Kinase A
Uncharacterized protein SAUSA300_1119 experimental SAS data
Molecular insights into the structure and function of the Staphylococcus aureus fatty acid kinase. J Biol Chem 2024 Oct 24;300(12):107920
J Biol Chem 300(12):107920 (2024 Oct 24)
SEC-SAXS of the fusion protein MPB-MabR(Rv2242) - dimeric peak
Maltose/maltodextrin-binding periplasmic protein (D108A, K109A, E198A, N199A, K265A)Uncharacterized protein Rv2242 experimental SAS data
Domain architecture of the Mycobacterium tuberculosis MabR (Rv2242), a member of the PucR transcription factor family Heliyon 2024 Nov :e40494
Heliyon :e40494 (2024 Nov)
Full-length SARS-CoV-2 5'ge element stem-loop 5 (5_SL5)
full stem-loop 5 of SARS-CoV-2 5'genomic end experimental SAS data
Dissecting the Conformational Heterogeneity of Stem-Loop Substructures of the Fifth Element in the 5'-Untranslated Region of SARS-CoV-2. J Am Chem Soc 2024 Nov 6;146(44):30139-30154
J Am Chem Soc 146(44):30139-30154 (2024 Nov 6)
S9 carboxypeptidase from Bacillus subtilis (4 mg/ml)
Putative acylaminoacyl-peptidase experimental SAS data
Structural adaptations for carboxypeptidase activity in putative S9 acylaminoacyl peptidase from Bacillus subtilis. Int J Biol Macromol 2024 Oct 19;:136734
Int J Biol Macromol :136734 (2024 Oct 19)
Cereblon-midi (CRBNmidi), an engineered Cereblon construct for crystallographic and biophysical studies, bound to Mezigdomide
Cereblon-midimezigdomide experimental SAS data
Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders Nature Communications 2024 Oct 15 15(1)
Nature Communications 15(1) (2024 Oct 15)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.