Curated repository for small angle scattering data and models


SASBDB currently contains:


976

experimental data sets

1463

models
273 experimental data sets on hold
326 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDEP9 – Cyclic GMP-AMP synthase (cGAS)

Cyclic GMP-AMP synthase experimental SAS data
Cyclic GMP-AMP synthase (cGAS) Rg histogram
Sample: Cyclic GMP-AMP synthase monomer, 61 kDa Homo sapiens protein
Buffer: 20 mM HEPES, pH: 7.4
Experiment: SAXS data collected at EMBL P12, PETRA III on 2017 Apr 25
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity. EMBO Rep (2019)
Liu H, Moura-Alves P, Pei G, Mollenkopf HJ, Hurwitz R, Wu X, Wang F, Liu S, Ma M, Fei Y, Zhu C, Koehler AB, Oberbeck-Mueller D, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B, Tuukkanen A, Kolbe M, Dorhoi A, Kaufmann SH
RgGuinier 3.1 nm
Dmax 12.7 nm
VolumePorod 110 nm3

SASDDH8 – Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant A1468R
Integrin beta-4 (1436-1666) A1468R experimental SAS data
Integrin beta4, fragment of the cytoplasmic region that includes the final part of the connecting segment and the third and fourth FnIII domains (FnIII-3,4). Point mutant A1468R Rg histogram
Integrin α6β4 recognition of a linear motif of bullous pemphigoid antigen BP230 controls its recruitment to hemidesmosomes: Supplemental figures S1 to S10 and table S1
SASDDQ4 – LIM/homeobox protein Lhx4 LIM domains fused to the LIM interaction domain (LID) of Insulin gene enhancer protein ISL-2
LIM/homeobox protein Lhx4Insulin gene enhancer protein ISL-2 experimental SAS data
DAMMIN model
Mutation in a flexible linker modulates binding affinity for modular complexes.
SASDD33 – Toxin/Antitoxin complex from M. tuberculosis
Mycobacterial cidal toxinMycobacterial cidal antitoxin experimental SAS data
PDB model
An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.
SASDDG5 – Mammalian prion protein mRNA (PrP mRNA wild type)
octo-repeat PrP mRNA experimental SAS data
DAMFILT model
Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.
SASDES5 – Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 (mmNT-SRCR3) - from SEC-SAXS
Mouse Neurotrypsin Scavenger Receptor Cysteine-Rich Domain 3 experimental SAS data
PDB model
Structural characterization of the third scavenger receptor cysteine-rich domain of murine Neurotrypsin

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