Curated repository for small angle scattering data and models


SASBDB currently contains:


1006

experimental data sets

1499

models
274 experimental data sets on hold
310 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDDH9 – Chloroplastic phosphoribulokinase (collected using SEC-SAXS)

Phosphoribulokinase, chloroplastic experimental SAS data
PDB model
Sample: Phosphoribulokinase, chloroplastic dimer, 78 kDa Chlamydomonas reinhardtii protein
Buffer: Tris-HCl 50 mM 150 mM KCl, pH: 7.5
Experiment: SAXS data collected at BM29, ESRF on 2016 Feb 15
Arabidopsis and Chlamydomonas phosphoribulokinase crystal structures complete the redox structural proteome of the Calvin-Benson cycle. Proc Natl Acad Sci U S A 116(16):8048-8053 (2019)
Gurrieri L, Del Giudice A, Demitri N, Falini G, Pavel NV, Zaffagnini M, Polentarutti M, Crozet P, Marchand CH, Henri J, Trost P, Lemaire SD, Sparla F, Fermani S
RgGuinier 3.4 nm
Dmax 11.3 nm
VolumePorod 115 nm3

SASDE56 – Human ATP-citrate synthase (ACLY) in HBS + Citrate + Coenzyme-A
ATP-citrate synthase experimental SAS data
SASREF CV model
Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle
SASDC28 – Mature alpha-DsbN protein
thiol-disulfide exchange protein experimental SAS data
DAMMIN model
The atypical thiol–disulfide exchange protein α-DsbA2 from Wolbachia pipientis is a homotrimeric disulfide isomerase
SASDER4 – Wild-type suppressor of copper sensitivity C protein, PmScsC, with concentration series data
Suppressor of Copper Sensitivity C protein experimental SAS data
OTHER model
Engineered variants provide new insight into the structural properties important for activity of the highly dynamic, trimeric protein disulfide isomerase ScsC from Proteus mirabilis
SASDFB2 – Urokinase plasminogen activator surface receptor, uPAR, K50C-V70C
Urokinase plasminogen activator surface receptor experimental SAS data
DAMMIN model
Did evolution create a flexible ligand-binding cavity in the urokinase receptor through deletion of a plesiotypic disulfide bond?
SASDEP9 – Cyclic GMP-AMP synthase (cGAS)
Cyclic GMP-AMP synthase experimental SAS data
Cyclic GMP-AMP synthase (cGAS) Rg histogram
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity.

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