Curated repository for small angle scattering data and models


SASBDB currently contains:


2004

experimental data sets

2993

models
520 experimental data sets on hold
594 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDLL3 – SH3 and multiple ankyrin repeat domains protein 3 with a point mutation (R12C)

SH3 and multiple ankyrin repeat domains protein 3 experimental SAS data
CORAL model
Sample: SH3 and multiple ankyrin repeat domains protein 3 monomer, 87 kDa Rattus norvegicus protein
Buffer: 100mM NaH2PO4, 100mM NaCl, 0.5mM DTT,, pH: 6.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2018 Jun 3
Autism associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses. Elife 10 (2021)
Bucher M, Niebling S, Han Y, Molodenskiy D, Nia FH, Kreienkamp HJ, Svergun D, Kim E, Kostyukova AS, Kreutz MR, Mikhaylova M
RgGuinier 4.1 nm
Dmax 13.8 nm
VolumePorod 175 nm3

ADAMTS-13 bound to von Willebrand Factor peptide
von Willebrand factorA disintegrin and metalloproteinase with thrombospondin motifs 13 experimental SAS data
An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution. J Mol Biol 2021 Mar 24;433(13):166954
J Mol Biol 433(13):166954 (2021 Mar 24)
The chaperone protein IpgC/invasin IpaB heterodimer complex from Shigella flexneri
T3SS Chaperone protein IpgCInvasin IpaB experimental SAS data
Structural Insights of Shigella Translocator IpaB and Its Chaperone IpgC in Solution Frontiers in Cellular and Infection Microbiology 2021 Apr 29 11
Frontiers in Cellular and Infection Microbiology 11 (2021 Apr 29)
Rationally optimised WA20 (ROWA) dimer
Rationally optimised WA20 mutant N22A/H86K (ROWA) dimer experimental SAS data
Rational thermostabilisation of four-helix bundle dimeric de novo proteins. Sci Rep 2021 Apr 6;11(1):7526
Sci Rep 11(1):7526 (2021 Apr 6)
Transcriptional intermediary factor 2 (TIF2) intrinsically disordered coactivator
Nuclear receptor coactivator 2 experimental SAS data
Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J Mol Biol 2021 Feb 27;433(9):166899
J Mol Biol 433(9):166899 (2021 Feb 27)
Two titin I27 domains linked with GGG linker
Two titin I27 domains linked with GGG linker experimental SAS data
Interdomain linkers tailor the stability of immunoglobulin repeats in polyproteins. Biochem Biophys Res Commun 2021 Apr 23;550:43-48
Biochem Biophys Res Commun 550:43-48 (2021 Apr 23)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.