Curated repository for small angle scattering data and models


SASBDB currently contains:


2489

experimental data sets

3584

models
428 experimental data sets on hold
518 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDLU2 – 2:1 complex between anti prion protein monoclonal IgG 6D11 and recombinant murine prion protein

Major prion proteinAnti-prion protein monoclonal IgG2a 6D11 experimental SAS data
OTHER model
Sample: Major prion protein monomer, 23 kDa Mus musculus protein
Anti-prion protein monoclonal IgG2a 6D11 monomer, 145 kDa Mus musculus protein
Buffer: phosphate buffered saline, pH: 7.4
Experiment: SAXS data collected at EMBL P12, PETRA III on 2019 Dec 15
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies. Sci Adv 7(48):eabj1826 (2021)
Linsenmeier L, Mohammadi B, Shafiq M, Frontzek K, Bär J, Shrivastava AN, Damme M, Song F, Schwarz A, Da Vela S, Massignan T, Jung S, Correia A, Schmitz M, Puig B, Hornemann S, Zerr I, Tatzelt J, Biasini E, Saftig P, Schweizer M, Svergun D, Amin L, Mazzola F, Varani L, Thapa S, Gilch S, Schätzl H, Harris DA, Triller A, Mikhaylova M, Aguzzi A, Altmeppen HC, Glatzel M
RgGuinier 8.1 nm
Dmax 24.8 nm
VolumePorod 710 nm3

Minimal trans Varkud Satellite (VS) ribozyme in 5mM MgCl2
Neurospora Varkud Satellite minimal trans ribozyme experimental SAS data
An integrative NMR-SAXS approach for structural determination of large RNAs defines the substrate-free state of a trans -cleaving Neurospora Varkud Satellite ribozyme Nucleic Acids Research 2021 Oct 28
Nucleic Acids Research (2021 Oct 28)
LDLa linker region of human Relaxin receptor 2 (RXFP2, 38-105)
Relaxin receptor 2 experimental SAS data
Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2. J Mol Biol 2021 Oct 15;433(21):167217
J Mol Biol 433(21):167217 (2021 Oct 15)
Tau protein, 2N4R isoform
Microtubule-associated protein tau, 2N4R isoform experimental SAS data
The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau Frontiers in Molecular Biosciences 2021 Oct 28 8
Frontiers in Molecular Biosciences 8 (2021 Oct 28)
Sensory rhodopsin II - transducer complex (NpSRII/NpHtrII) in detergent at 150 mM NaCl studied with SAXS
Sensory rhodopsin II from Natronbacterium pharaonisSensory rhodopsin II transducer from Natronomonas pharaonis experimental SAS data
Ambiguities in and completeness of SAS data analysis of membrane proteins: the case of the sensory rhodopsin II–transducer complex Acta Crystallographica Section D Structural Biology 2021 Oct 20 77(11)
Acta Crystallographica Section D Structural Biology 77(11) (2021 Oct 20)
Complex of Archaeoglobus fulgidus Argonaute with dsDNA (5'p-ATTGTACGTACAAT)
Piwi protein AF_13185'-phosphorilated 14-mer DNA oligoduplex experimental SAS data
Prokaryotic Argonaute from Archaeoglobus fulgidus interacts with DNA as a homodimer. Sci Rep 2021 Feb 25;11(1):4518
Sci Rep 11(1):4518 (2021 Feb 25)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated and validated repository for biological scattering data. Protein Science 29(1); 66-75.