Curated repository for small angle scattering data and models


SASBDB currently contains:


1684

experimental data sets

2640

models
497 experimental data sets on hold
549 models on hold

Small angle scattering (SAS) of X-ray and neutrons provides structural information on biological macromolecules in solution at a resolution of 1-2 nm.
SASBDB is a fully searchable curated repository of freely accessible and downloadable experimental data, which are deposited together with the relevant experimental conditions, sample details, derived models and their fits to the data.

Recent depositions:

SASDFS7 – Talin-1 head amino acids 1-405(Δ139-168)

Talin-1 (Δ139-168), human experimental SAS data
Talin-1 head amino acids 1-405(Δ139-168) Rg histogram
Sample: Talin-1 (Δ139-168), human monomer, 48 kDa Homo sapiens protein
Buffer: 50 mM sodium phosphate, 150mM NaCl, pH: 7.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2015 Sep 24
The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering. J Cell Sci 133(19) (2020)
Kukkurainen S, Azizi L, Zhang P, Jacquier MC, Baikoghli M, von Essen M, Tuukkanen A, Laitaoja M, Liu X, Rahikainen R, Orłowski A, Jänis J, Määttä JAE, Varjosalo M, Vattulainen I, Róg T, Svergun D, Cheng RH, Wu J, Hytönen VP, Wehrle-Haller B
RgGuinier 3.3 nm
Dmax 13.3 nm
VolumePorod 77 nm3

Rov C - Regulator Of Virulence interconnected with the Csr system (hexameric transcriptional activator of type VI secretion gene expression)
Regulator Of Virulence interconnected with the Csr system experimental SAS data
RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression PLOS Pathogens 2020 Sep 23 16(9):e1008552
PLOS Pathogens 16(9):e1008552 (2020 Sep 23)
In cellulo Woronin body major protein (HEX-1) crystals recombinantly expressed within High Five insect cells
Woronin body major protein experimental SAS data
Woronin body major protein Kratky plot
Rapid screening of in cellulo grown protein crystals via a small-angle X-ray scattering/X-ray powder diffraction synergistic approach Journal of Applied Crystallography 2020 Sep 25 53(5)
Journal of Applied Crystallography 53(5) (2020 Sep 25)
Heat shock protein 70 (PfHSP70-1)
Heat shock protein 70Peptide experimental SAS data
Structural-functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding. Biochem J 2020 Sep 30;477(18):3625-3643
Biochem J 477(18):3625-3643 (2020 Sep 30)
BceAB-type ABC-Transporter nucleotide-binding domain, SaNsrF
ABC transporter, ATP-binding protein (Nucleotide-Binding Domain SaNsrF) experimental SAS data
Characterization of the nucleotide-binding domain NsrF from the BceAB-type ABC-transporter NsrFP from the human pathogen Streptococcus agalactiae Scientific Reports 2020 Sep 16 10(1)
Scientific Reports 10(1) (2020 Sep 16)
Type 3 secretion system pilotin, InvH27-147
Type 3 secretion system pilotin experimental SAS data
Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods. Structure 2020 Aug 27;
Structure (2020 Aug 27)

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To cite SASBDB refer to: Kikhney AG, Borges CR, Molodenskiy DS, Jeffries CM, Svergun DI (2020) SASBDB: Towards an automatically curated andvalidated repository for biological scattering data. Protein Science 29(1); 66-75.