Proto-oncogene tyrosine-protein kinase Src

c-Src WT protein

Organism: Homo sapiens

Monomeric molecular weight: 51.9 kDa

Oligomeric state: Monomer

Total molecular weight: 51.9 kDa

UniProt: P12931 (84-536)

Sequence:

GSDIGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

The protein domains adopt a closed conformation. TEV proteolytic cleavage leaves an additional GSDI N-terminal amino acid extension (from sub-cloning into an EcoRV cloning site of the protein expression plasmid).