Collagen alpha-2(VI) chain (R680H, K966N, Q967E)

ColVIa2 protein

Organism: Homo sapiens

Monomeric molecular weight: 52.5 kDa

Oligomeric state: Other

Total molecular weight: 52.5 kDa

UniProt: P12110 (564-1019)

Sequence:

ETGSAWSHPQFEKGGGGSGGGGSGEPGPRGPRGVPGPEGEPGPPGDPGLTECDVMTYVRETCGCCDCEKRCGALDVVFVIDSSESIGYTNFTLEKNFVINVVNRLGAIAKDPKSETGTRVGVVQYSHEGTFEAIQLDDEHIDSLSSFKEAVKNLEWIAGGTWTPSALKFAYDRLIKESRRQKTRVFAVVITDGRHDPRDDDLNLRALCDRDVTVTAIGIGDMFHEKHESENLYSIACDKPQQVRNMTLFSDLVAEKFIDDMEDVLCPDPQIVCPDLPCQTELSVAQCTQRPVDIVFLLDGSERLGEQNFHKARRFVEQVARRLTLARRDDDPLNARVALLQFGGPGEQQVAFPLSHNLTAIHEALETTQYLNSFSHVGAGVVHAINAIVRSPRGGARRHAELSFVFLTDGVTGNDSLHESAHSMRNENVVPTVLALGSDVDMDVLTTLSLGDRAAVFHEKDYDSLAQPGFFDRFIRWIC

C-terminal fragment of Collagen alpha-2(VI) chain. Collagen VI acts as a cell-binding protein. The protein construct used for SAXS contains an additional non-native N-terminal extension (ETGSAWSHPQFEKGGGGSGGGGS) and three point mutations relative to the canonical UniProt sequence (R680H, K966N, Q967E).