Angiotensin Converting Enzyme2
ACE 2 protein
Organism: Homo sapiens
Monomeric molecular weight: 92.4 kDa
Oligomeric state:
Dimer
Total molecular weight: 185 kDa
ACE2 converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Its C-terminal is homologous to collection and is also responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction, regulating its expression on the cell surface and its catalytic activity.