3 Chymotrypsin Like Protease

3CL pro protein

Organism: Severe acute respiratory syndrome coronavirus 2

Monomeric molecular weight: 33.8 kDa

Oligomeric state: Dimer

Total molecular weight: 67.6 kDa

UniProt: P0DTC1 (3264-3569)

Sequence:

>SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ

M protease of SARS CoV-2 with an inhouse compound JL-352 ( incubated for 30 minutes). The compounds showed significant reduction in the activity of M protease protein. The protein is essential in the viral polyprotein activation. The protein activate the entire the polyprotein of the virus inside the host cell.