RNA-directed RNA polymerase nsP4

RdRp nsP4 protein

Organism: O'nyong-nyong virus

Monomeric molecular weight: 68.3 kDa

Oligomeric state: Monomer

Total molecular weight: 68.3 kDa

UniProt: O90368 (1903-2513)

Sequence:

YIFSSDTGQGHLQQKSVRQTTLPVNIVEEVHEEKCYPPKLDEIKEQLLLKRLQESASTAN RSRYQSRKVENMKAMIIHRLKEGCRLYLASDTPRVPSYRITYPAPIYSPSINIKLSNPET AVAVCNEFLARNYPTVASYQVTDEYDAYLDMVDGSESCLDRATFNPSKLRSYPKQHSYHA PTIRSAVPSPFQNTLQNVLAAATKRNCNVTQMRELPTMDSAAFNVECFKKYACNQEYWRE FASSPIRVTTENLTTYVTKLKGPKAAALFAKTHNLLPLQEVPMDRFTMDMKRDVKVTPGT KHTEERPKVQVIQAAEPLATAYLCGIHRELVRRLNAVLLPNVHTLFDMSAEDFDAIIATH FKPGDAVLETDIASFDKSQDDSLALTAMMLLEDLGVDQPILDLIEAAFGEISSCHLPTGT RFKFGAMMKSGMFLTLFVNTLLNITIASRVLEERLTTSACAAFIGDDNIIHGVVSDALMA ARCATWMNMEVKIIDAVVSVKAPYFCGGFILHDTVTGTACRVADPLKRLFKLGKPLAAGD EQDEDRRRALADEVTRWQRTGLVTELERAVYSRYEVQGITAVITSMATFASSKENFKKLR GPVVTLYGGPK

Replicates genomic and antigenomic RNA by recognizing replications specific signals. The early replication complex formed by the polyprotein P123 and nsP4 synthesizes minus-strand RNAs.