An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation

EswarKumar N, Yang C, Tewary S, Peng W, Chen G, Yeh Y, Yang H, Ho M
Structure (2023 Oct)

doi: 10.1016/j.str.2023.09.004 		Submitted to SASBDB: 2020 Apr 29
Published in SASBDB:

SASDJ33 – Receptor-type tyrosine-protein phosphatase epsilon bound to phospho proto-oncogene tyrosine-protein kinase (rPTPε/phospho-Src complex)

Receptor-type tyrosine-protein phosphatase epsilonProto-oncogene tyrosine-protein kinase Src, T357M mutant experimental SAS data
CORAL model
Sample: Receptor-type tyrosine-protein phosphatase epsilon monomer, 34 kDa Homo sapiens protein
Proto-oncogene tyrosine-protein kinase Src, T357M mutant monomer, 31 kDa Homo sapiens protein
Buffer: 20 mM Tris , 50 mM NaCl, 5 mM DTT, pH: 8
Experiment: SAXS data collected at 23A1, Taiwan Photon Source, NSRRC on 2017 May 26
RgGuinier 2.9 nm
Dmax 10.0 nm
VolumePorod 60 nm3