Structural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.

Sutinen A, Nguyen GTT, Raasakka A, Muruganandam G, Loris R, Ylikallio E, Tyynismaa H, Bartesaghi L, Ruskamo S, Kursula P
FEBS Open Bio (2022 May 4)

PMID: 35509130 doi: 10.1002/2211-5463.13422

Submitted to SASBDB: 2022 Feb 22 Published in SASBDB: 2022 May 16

SASDND6 – Human ganglioside-induced differentiation-associated protein 1 (GDAP1) missense mutant H123R, construct GDAP1∆302-358 Sample: Ganglioside-induced differentiation-associated protein 1 (H123R) dimer, 70 kDa Homo sapiens protein Buffer: 25 mM HEPES, 300 mM NaCl, pH: 7.5 Experiment: SAXS data collected at SWING, SOLEIL on 2020 Oct 8 RgGuinier 3.1 nm Dmax 9.9 nm VolumePorod 107 nm3

SASDNE6 – Human ganglioside-induced differentiation-associated protein 1 (GDAP1) missense mutant R120W, construct GDAP1∆302-358 Sample: Ganglioside-induced differentiation-associated protein 1 (R120W) dimer, 70 kDa Homo sapiens protein Buffer: 25 mM HEPES, 300 mM NaCl, pH: 7.5 Experiment: SAXS data collected at SWING, SOLEIL on 2020 Jul 1 RgGuinier 3.1 nm Dmax 10.0 nm VolumePorod 105 nm3