The crystal structure of the TPR domain of the EccA5 ATPase and demonstration of its interaction with EspG5 from the mycobacterial ESX-5 pathway.

Sharma VK, Vishwakarma J, Kabrambam R, Kumar S, Ramachandran R
FEBS Lett (2026 Feb 28)
PMID: 41761896
doi: 10.1002/1873-3468.70315 		Submitted to SASBDB: 2022 Jun 16
Published in SASBDB:

SASDPJ4 – N-terminal domain of EccA5

ESX-5 secretion system protein EccA5 experimental SAS data
DAMMIF model
Sample: ESX-5 secretion system protein EccA5 monomer, 31 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 20 mM Tris, 150 mM NaCl, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2018 Mar 9
RgGuinier 2.6 nm
Dmax 7.8 nm
VolumePorod 57 nm3

SASDWE7 – EccA5-N terminal domain and EspG5 complex of Mycobacterium tuberculosis

ESX-5 secretion-associated protein EspG5ESX-5 secretion system protein EccA5 experimental SAS data
DAMFILT model
Sample: ESX-5 secretion-associated protein EspG5 monomer, 32 kDa Mycobacterium tuberculosis (strain … protein
ESX-5 secretion system protein EccA5 monomer, 31 kDa Mycobacterium tuberculosis (strain … protein
Buffer: 50 mM HEPES, 200 mM NaCl, pH: 8
Experiment: SAXS data collected at Anton Paar SAXSpace, CSIR-Central Drug Research Institute on 2025 Jan 28
RgGuinier 3.5 nm
Dmax 9.1 nm
VolumePorod 83 nm3