Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design.

Shaw GX, Fan L, Cherry S, Shi G, Tropea JE, Ji X
Curr Res Struct Biol 5:100095 (2023)
PMID: 36820301
doi: 10.1016/j.crstbi.2023.100095 		Submitted to SASBDB: 2025 Feb 12
Published in SASBDB:

SASDWA7 – Dihydroneopterin aldolase from H.pylori (HpDHNA:Pterin)

Dihydroneopterin aldolase experimental SAS data
DAMMIN model
Sample: Dihydroneopterin aldolase tetramer, 55 kDa Helicobacter pylori (strain … protein
Buffer: 25 mM Tris-HCl pH 7.5 and 150 mM NaCl, pH: 7.5
Experiment: SAXS data collected at 12-ID-B SAXS/WAXS, Advanced Photon Source (APS), Argonne National Laboratory on 2019 Apr 5
RgGuinier 2.5 nm
Dmax 7.3 nm
VolumePorod 77 nm3