The 5'-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH.

Toews S, Wacker A, Faison EM, Duchardt-Ferner E, Richter C, Mathieu D, Bottaro S, Zhang Q, Schwalbe H
Nucleic Acids Res (2024 Jun 6)
PMID: 38842942
doi: 10.1093/nar/gkae477
Submitted to SASBDB: 2023 Jul 31
Published in SASBDB:

SASDSP7 – 5’-terminal stem-loop 1 RNA element of SARS-CoV-2 (5_SL1)

5_SL1 experimental SAS data
DAMMIN model
Sample: 5_SL1 monomer, 9 kDa Severe acute respiratory … RNA
Buffer: 50 mM BisTris, 25 mM NaCl, pH: 6.2
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Dec 1
RgGuinier 1.7 nm
Dmax 5.5 nm
VolumePorod 16 nm3