An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Cuesta-Hernández H, Contreras J, Soriano-Maldonado P, Sánchez-Wandelmer J, Yeung W, Martín-Hurtado A, Muñoz I, Kannan N, Llimargas M, Muñoz J, Plaza-Menacho I
Nature Communications 14(1) (2023 Oct 17)

doi: 10.1038/s41467-023-41890-7 		Submitted to SASBDB: 2023 Aug 24
Published in SASBDB:

SASDSV8 – Tyrosine-protein kinase Src (c-Src WT)

Proto-oncogene tyrosine-protein kinase Src experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Proto-oncogene tyrosine-protein kinase Src monomer, 52 kDa Homo sapiens protein
Buffer: 20 mM Tris pH 8.0, 150 mM NaCl, 1% glycerol and 1 mM DTT, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 May 8
RgGuinier 2.6 nm
Dmax 8.9 nm
VolumePorod 67 nm3