Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring.

Gadeberg TAF, Jørgensen MH, Olesen HG, Lorentzen J, Harwood SL, Almeida AV, Fruergaard MU, Jensen RK, Kanis P, Pedersen H, Tranchant E, Petersen SV, Thøgersen IB, Kragelund BB, Lyons JA, Enghild JJ, Andersen GR
Nat Struct Mol Biol (2025 Jan 23)
PMID: 39849196
doi: 10.1038/s41594-024-01467-4
Submitted to SASBDB: 2024 Jan 9
Published in SASBDB:

SASDTU8 – Complement C3* at 1.25 mg/mL (pH 6.0, 200 mM NaCl)

Complement C3 (Δ668-671) experimental SAS data
CORAL model
Sample: Complement C3 (Δ668-671) monomer, 187 kDa Homo sapiens protein
Buffer: 20 mM MES pH 6.0, 200 mM NaCl, pH: 6
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Nov 7
RgGuinier 5.4 nm
Dmax 21.8 nm
VolumePorod 357 nm3