Semi-synthesis of TDP-43 reveals the effects of phosphorylation in N-terminal domain on self-association

Sasaki D, Tenda M, Sohma Y
Communications Chemistry 8(1) (2025 Apr 25)

doi: 10.1038/s42004-025-01522-1 		Submitted to SASBDB: 2024 Jul 5
Published in SASBDB:

SASDV74 – Ser48-phosphorylated N-terminal domain of transactive response DNA-binding protein 43 (TDP-43)

TAR DNA-binding protein 43 experimental SAS data
DAMMIF model
Sample: TAR DNA-binding protein 43 monomer, 9 kDa Homo sapiens protein
Buffer: 50 mM Tris-HCl, 150 mM NaCl, 1 mM DTT, 3% glycerol,, pH: 8.5
Experiment: SAXS data collected at BL38B1, SPring-8 on 2024 May 29
RgGuinier 1.4 nm
Dmax 4.3 nm
VolumePorod 15 nm3