Anemia-associated mutations disrupt the CDIN1-Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA-I) disease.

Stojaspal M, Brom T, Nečasová I, Janovič T, Veverka P, Verma N, Uhrík L, Hernychova L, Hofr C
FEBS J (2026 Jan 29)

PMID: 41609415 doi: 10.1111/febs.70421

Submitted to SASBDB: 2024 Jul 10 Published in SASBDB: 2026 Feb 2

SASDVJ4 – Complex of CDAN1-interacting nuclease 1 and Codanin1 C-terminal domain (frames 712 - 720) Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein CDAN1-interacting nuclease 1 monomer, 33 kDa Homo sapiens protein Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29 RgGuinier 3.0 nm Dmax 10.6 nm VolumePorod 102 nm3

SASDV49 – Human Codanin1 C-terminal domain (frames 842 - 851) Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29 RgGuinier 2.4 nm Dmax 7.4 nm VolumePorod 46 nm3

SASDV39 – Human CDAN1-interacting nuclease 1 (frames 692 - 701) Sample: CDAN1-interacting nuclease 1 monomer, 33 kDa Homo sapiens protein Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29 RgGuinier 2.8 nm Dmax 8.9 nm VolumePorod 104 nm3

SASDVG4 – Human CDAN1-interacting nuclease 1 (frames 717 - 723) Sample: CDAN1-interacting nuclease 1 dimer, 67 kDa Homo sapiens protein Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29 RgGuinier 2.8 nm Dmax 9.9 nm VolumePorod 85 nm3

SASDVH4 – Human Codanin1 C-terminal domain (frames 779 - 791) Sample: Codanin-1 monomer, 25 kDa Homo sapiens protein Buffer: 20 mM Tris HCl, 150 mM NaCl, 5% glycerol, pH: 8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Sep 29 RgGuinier 2.5 nm Dmax 9.3 nm VolumePorod 51 nm3