A SELECTIVE ALTERNATIVE PATHWAY COMPLEMENT INHIBITOR FOR TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Hagen Sülzen Submitted to SASBDB: 2024 Jul 4
Published in SASBDB:

SASDV84 – SH-01 in complex with Fab 3E12

SH-01Fab 3E12 experimental SAS data
DAMMIN model
Sample: SH-01 monomer, 41 kDa protein
Fab 3E12 monomer, 50 kDa Mus musculus protein
Buffer: 20 mM HEPES, 150 mM NaCl, 3% glycerol, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2023 Jun 15
RgGuinier 3.8 nm
Dmax 14.0 nm
VolumePorod 124 nm3