Molecular virulence mechanism of phospholipase C from Pseudomonas aeruginosa

Sabharwal N, Ge Y, Lunelli M, Sae-Ueng U, Jeffries C, Chatziefthymiou S, Srivastava S, Tumeh A, Geisler A, Kolbe M, Labahn J
Protein & Cell (2026 Sep 01)

doi: 10.1093/procel/pwag062 		Submitted to SASBDB: 2025 Aug 1
Published in SASBDB:

SASDV94 – Phospholipase C (PLC H) bound to the chaperone PLC R2 (PLC H/R2 complex)

phospholipase CPhospholipase C accessory protein PlcR experimental SAS data
ALPHAFOLD model
Sample: Phospholipase C monomer, 84 kDa Pseudomonas aeruginosa (strain … protein
Phospholipase C accessory protein PlcR monomer, 19 kDa Pseudomonas sp. FDAARGOS_761 protein
Buffer: 25 mM Tris pH 7.5, 100 mM NaCl, 3 mM β-mercaptoethanol, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 Dec 16
RgGuinier 3.1 nm
Dmax 12.0 nm
VolumePorod 156 nm3