The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase

Martín-Hurtado A, Contreras J, Sánchez-Wandelmer J, Zarzuela E, García F, Le Coq J, Boskovic J, Muñoz I, Gago F, Muñoz J, Isasa M, Plaza-Menacho I
Nature Communications (2026 Mar 06)

doi: 10.1038/s41467-026-69833-y 		Submitted to SASBDB: 2026 Mar 16
Published in SASBDB:

SASDVB5 – CCDC6-RET fusion protein variant c

CCDC6-RET fusion protein variant c (K147M, Δ216-229) experimental SAS data
DAMMIN model
Sample: CCDC6-RET fusion protein variant c (K147M, Δ216-229) dimer, 86 kDa Homo sapiens protein
Buffer: 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2023 Sep 18
RgGuinier 5.5 nm
Dmax 19.5 nm
VolumePorod 260 nm3