Structural basis for regulation of CELSR1 by a compact module in its extracellular region.

Bandekar SJ, Garbett K, Kordon SP, Dintzner EE, Li J, Shearer T, Sando RC, Araç D
Nat Commun 16(1):3972 (2025 Apr 28)
PMID: 40295529
doi: 10.1038/s41467-025-59319-8 		Submitted to SASBDB: 2024 Oct 3
Published in SASBDB:

SASDVS7 – Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) ECR without calcium

Cadherin EGF LAG seven-pass G-type receptor 1 experimental SAS data
Cadherin EGF LAG seven-pass G-type receptor 1 Kratky plot
Sample: Cadherin EGF LAG seven-pass G-type receptor 1 monomer, 245 kDa Mus musculus protein
Buffer: 10 mM Tris, 150 mM NaCl, pH: 8.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Dec 8
RgGuinier 6.0 nm
Dmax 22.5 nm
VolumePorod 473 nm3

SASDVT7 – Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) ECR with calcium

Cadherin EGF LAG seven-pass G-type receptor 1 experimental SAS data
Cadherin EGF LAG seven-pass G-type receptor 1 Kratky plot
Sample: Cadherin EGF LAG seven-pass G-type receptor 1 dimer, 491 kDa Mus musculus protein
Buffer: 10 mM Tris, 150 mM NaCl, 1 mM CaCl2, pH: 8.5
Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2022 Dec 8
RgGuinier 16.2 nm
Dmax 67.5 nm
VolumePorod 722 nm3