Structural basis for therapeutic antibody binding to CCN2 and its mechanisms on TGF-β family signaling

Haben Gabir Submitted to SASBDB: 2024 Oct 28
Published in SASBDB:

SASDV69 – Mouse Central Communication Network 2 (N-terminal Fragment)

Cellular communication network factor 2 experimental SAS data
Sample: Cellular communication network factor 2 monomer, 36 kDa protein
Buffer: 50 mM Tris pH 7.5, 200 mM NaCl, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 May 6
RgGuinier 2.1 nm
Dmax 7.1 nm
VolumePorod 29 nm3

SASDV79 – Mouse Central Communication Network 2 (CCN2) in complex with anti-CCN2 F(ab) antibody 37-45-MH1

Cellular communication network factor 2anti-CCN2 37-45-MH1 F(ab) antibody experimental SAS data
Sample: Cellular communication network factor 2 monomer, 36 kDa protein
Anti-CCN2 37-45-MH1 F(ab) antibody monomer, 49 kDa protein
Buffer: 50 mM Tris pH 7.5, 200 mM NaCl, pH: 7.5
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 May 6
RgGuinier 3.3 nm
Dmax 11.9 nm
VolumePorod 95 nm3