The OSCP Subunit of ATP Synthase is a Dimer in Solution: Strategy to Induce the Monomeric Protein as a New Tool for Drug Discovery.

Fabbian S, Gabbatore L, Morbiato L, Zotti M, Giorgio V, Battisutta R, Giachin G, Sosic A, Bellanda M
J Mol Biol 437(17):169267 (2025 Jun 6)
PMID: 40482958
doi: 10.1016/j.jmb.2025.169267 		Submitted to SASBDB: 2024 Nov 12
Published in SASBDB:

SASDVQ9 – Full-length mature human mitochondrial ATP synthase subunit O (Oligomycin Sensitivity Conferral Protein or Complex V subunit O)

ATP synthase subunit O, mitochondrial experimental SAS data
ALPHAFOLD model
Sample: ATP synthase subunit O, mitochondrial dimer, 42 kDa Homo sapiens protein
Buffer: 50 mM Na2HPO4, 300 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2022 Mar 15
RgGuinier 3.7 nm
Dmax 12.0 nm
VolumePorod 78 nm3

SASDVR9 – C-terminal tail of human mitochondrial ATP synthase subunit O (137-213) (Oligomycin Sensitivity Conferral Protein or Complex V subunit O)

ATP synthase subunit O, mitochondrial C-terminal section experimental SAS data
ALPHAFOLD model
Sample: ATP synthase subunit O, mitochondrial C-terminal section trimer, 25 kDa Homo sapiens protein
Buffer: 50 mM Na2HPO4, 300 mM NaCl, pH: 7
Experiment: SAXS data collected at BM29, ESRF on 2022 Mar 15
RgGuinier 2.1 nm
Dmax 6.5 nm
VolumePorod 32 nm3