Collagen VI Microfibril Structure Reveals the Mechanism for Heterotrimerisation and the Clustering of Inherited Pathogenic Mutations

Mark H. Becker Submitted to SASBDB: 2024 Nov 18
Published in SASBDB:

SASDWL2 – C-terminal mini-Collagen VI heterotrimer

Collagen alpha-1(VI) chainCollagen alpha-2(VI) chain (R680H, K966N, Q967E)Collagen alpha-3(VI) chain (D2357R, K2367R, D2431V, R2441T, R2609A, R2610A) experimental SAS data
ALPHAFOLD model
Sample: Collagen alpha-1(VI) chain, 52 kDa Homo sapiens protein
Collagen alpha-2(VI) chain (R680H, K966N, Q967E), 53 kDa Homo sapiens protein
Collagen alpha-3(VI) chain (D2357R, K2367R, D2431V, R2441T, R2609A, R2610A), 54 kDa Homo sapiens protein
Buffer: Tris-buffered saline, pH: 7.4
Experiment: SAXS data collected at B21, Diamond Light Source on 2022 Jul 27
RgGuinier 4.8 nm
Dmax 18.7 nm
VolumePorod 478 nm3