Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the Fab' region of IgA1 and IgA2.

Ramírez-Larrota JS, Juyoux P, Guerra P, Eckhard U, Gomis-Rüth FX
PLoS Pathog 21(7):e1013292 (2025 Jul)

PMID: 40627637
doi: 10.1371/journal.ppat.1013292

Submitted to SASBDB: 2025 Feb 27
Published in SASBDB: 2025 Jun 18

SASDX42 – IgA peptidase (A31-I1166; active site mutant E540A)

Sample:	IgA protease (E540A) monomer, 128 kDa Thomasclavelia ramosa protein
Buffer:	50 mM Tris, 150 mM NaCl, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2023 May 23