Unreleased project

Acylation of the RTX toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol

Chacko F, Ganz S, Pfitzer-Bilsing A, Hänsch S, Westhoff P, Weidtkamp-Peters S, Smits S, Exterkate M, Schmitt L
Biochimica et Biophysica Acta (BBA) - Biomembranes :184487 (2025 Nov)

doi: 10.1016/j.bbamem.2025.184487

Submitted to SASBDB: 2025 Apr 2 Published in SASBDB: 2025 Dec 1

SASDXF6 – RTX cytotoxin pro-MbxA without acylation (pro-MbxA) Sample: RTX cytotoxin pro-MbxA without acylation monomer, 100 kDa Moraxella bovis protein Buffer: 50 mM Tris, 100 mM NaCl, 10mM CaCl2, pH: 7.8 Experiment: SAXS data collected at EMBL P12, PETRA III on 2022 May 9 RgGuinier 3.8 nm Dmax 13.4 nm VolumePorod 154 nm3