DNA induces non-canonical dimerization of the farnesoid X receptor.

Khan SH, Yennawar N, Okafor CD
Nucleic Acids Res 54(4) (2026 Feb 5)
PMID: 41728955
doi: 10.1093/nar/gkag087 		Submitted to SASBDB: 2025 Apr 16
Published in SASBDB:

SASDXU3 – Farnesoid X Receptor Protein

Isoform 3 of Bile acid receptor experimental SAS data
ALPHAFOLD model
Sample: Isoform 3 of Bile acid receptor monomer, 41 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM NaCl, 5 % glycerol, 1 mM DTT, 20 µM CDCA, pH: 7.4
Experiment: SAXS data collected at Rigaku BioSAXS-2000, Pennsylvania State University on 2024 May 9
RgGuinier 3.5 nm
Dmax 11.6 nm
VolumePorod 75 nm3

SASDXV3 – Farnesoid X receptor homo-dimer bound to inverted repeat DNA

inverted repeat DNAIsoform 3 of Bile acid receptor experimental SAS data
ALPHAFOLD model
Sample: Inverted repeat DNA monomer, 11 kDa DNA
Isoform 3 of Bile acid receptor dimer, 83 kDa Homo sapiens protein
Buffer: 50 mM HEPES, 150 mM NaCl, 5 % glycerol, 1 mM DTT, 20 µM CDCA, pH: 7.4
Experiment: SAXS data collected at Rigaku BioSAXS-2000, Pennsylvania State University on 2024 May 9
RgGuinier 5.1 nm
Dmax 23.2 nm
VolumePorod 120 nm3