Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms

Hansen S, Bartual S, Yuan H, Raimi O, Gorelik A, Ferenbach A, Lytje K, Pedersen J, Drace T, Boesen T, van Aalten D
Nature Communications 16(1) (2025 Oct 03)

doi: 10.1038/s41467-025-63893-2 		Submitted to SASBDB: 2025 Jul 14
Published in SASBDB:

SASDXF6 – Multi-domain human O-GlcNAcase

Protein O-GlcNAcase experimental SAS data
ALPHAFOLD model
Sample: Protein O-GlcNAcase dimer, 163 kDa Homo sapiens protein
Buffer: 25 mM Tris buffer, 150 mM NaCl, and 0.5 mM TCEP, pH: 7.5
Experiment: SAXS data collected at Bruker Nanostar w Excillum source, Department of Chemistry, iNANO building, Aarhus Uinversity on 2023 Jun 22
RgGuinier 5.4 nm
Dmax 18.9 nm
VolumePorod 443 nm3