From TDP-43/RNA complex formation to disease-linked TDP-43 aggregation through a structural and cellular approach.

Feng Y, Joshi V, Pankivskyi S, Clément MJ, Rengifo-Gonzalez JC, Thureau A, Pastré D, Bouhss A
Nat Commun (2026 Jan 21)
PMID: 41565639
doi: 10.1038/s41467-026-68346-y 		Submitted to SASBDB: 2025 Sep 8
Published in SASBDB:

SASDXL8 – A nuclear mRNA-binding protein bound to GT-repeat DNA Oligo: TDP-43 (TAR DNA-binding protein 43)

TAR DNA-binding protein 43 experimental SAS data
TAR DNA-binding protein 43 Kratky plot
Sample: TAR DNA-binding protein 43 monomer, 63 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 100 mM KCl, 2 mM TCEP, pH: 7.6
Experiment: SAXS data collected at SWING, SOLEIL on 2022 Nov 30
RgGuinier 4.0 nm
Dmax 16.5 nm
VolumePorod 135 nm3