Conformational Flexibility and Transient Structure of the Proline-Rich Domain in p53.

Berggren A, Bakker M, Fisher H, Skepö M
Biophys J (2026 Mar 13)

PMID: 41832603 doi: 10.1016/j.bpj.2026.03.024

Submitted to SASBDB: 2025 Oct 18 Published in SASBDB: 2026 Mar 17

SASDY42 – p53 proline-rich domain of Cellular tumor antigen p53 with 150 mM NaCl and neutral pH Sample: Cellular tumor antigen p53 monomer, 4 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM NaCl,, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2025 Jan 30 RgGuinier 2.3 nm

SASDY52 – p53 proline-rich domain of Cellular tumor antigen p53 with 10 mM NaCl and neutral pH Sample: Cellular tumor antigen p53 monomer, 4 kDa Homo sapiens protein Buffer: 20 mM Tris, 10 mM NaCl,, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2025 Jan 30 RgGuinier 2.2 nm

SASDY62 – p53 proline-rich domain of Cellular tumor antigen p53 with (P72R) with 150 mM NaCl and neutral pH Sample: Cellular tumor antigen p53 P72R monomer, 4 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM NaCl,, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2025 Sep 25 RgGuinier 2.2 nm

SASDY72 – p53 proline-rich domain of Cellular tumor antigen p53 with(P72R) with 10 mM NaCl and neutral pH Sample: Cellular tumor antigen p53 P72R monomer, 4 kDa Homo sapiens protein Buffer: 20 mM Tris, 10 mM NaCl,, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2025 Sep 25 RgGuinier 2.3 nm

SASDY82 – p53 proline-rich domainof of Cellular tumor antigen p53 with Cellular tumor antigen p53 with (P82L) with 150 mM NaCl and neutral pH Sample: Cellular tumor antigen p53 P82L monomer, 4 kDa Homo sapiens protein Buffer: 20 mM Tris, 150 mM NaCl,, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2025 Sep 25 RgGuinier 2.2 nm

SASDY92 – p53 proline-rich domain of Cellular tumor antigen p53 with (P82L) with 10 mM NaCl and neutral pH Sample: Cellular tumor antigen p53 P82L monomer, 4 kDa Homo sapiens protein Buffer: 20 mM Tris, 10 mM NaCl,, pH: 7 Experiment: SAXS data collected at BM29, ESRF on 2025 Sep 25 RgGuinier 2.3 nm