Structure of a Stand-Alone Homodimeric NRPS Condensation Domain Reveals Occlusion of the Canonical Carrier-Protein Interface

Singh J, Grant T, Gulick A
(2026 Apr 28)

doi: 10.64898/2026.04.24.720670

Submitted to SASBDB: 2026 Apr 14 Published in SASBDB: 2026 May 13

SASDZW5 – The FAA Condensation Domain, OaaC from Coprococcus Eutactus (Plipastatin synthase subunit A) Sample: Condensation Domain from Coprococcus Eutactus dimer, 108 kDa Coprococcus eutactus ATCC … protein Buffer: 10mM HEPES pH 7.5, 50mM NaCl, 0.2mM TCEP, pH: 7.5 Experiment: SAXS data collected at 16-ID (LiX), National Synchrotron Light Source II (NSLS-II) on 2022 Dec 16 RgGuinier 3.2 nm Dmax 9.5 nm VolumePorod 184 nm3