The molecular basis for Apolipoprotein E4 as the major risk factor for late onset Alzheimer's disease.

Raulin AC, Kraft L, Al-Hilaly YK, Xue WF, McGeehan JE, Atack JR, Serpell L
J Mol Biol (2019 Apr 30)
PMID: 31051176
doi: 10.1016/j.jmb.2019.04.019 		Submitted to SASBDB: 2018 Jun 7
Published in SASBDB:

SASDDD7 – Apolipoprotein E2

Apolipoprotein E2 experimental SAS data
Apolipoprotein E2 Kratky plot
Sample: Apolipoprotein E2 tetramer, 139 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Nov 29
RgGuinier 5.6 nm
Dmax 19.5 nm
VolumePorod 400 nm3

SASDD98 – Apolipoprotein E3

Apolipoprotein E3 experimental SAS data
Apolipoprotein E3 Kratky plot
Sample: Apolipoprotein E3 tetramer, 139 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Nov 29
RgGuinier 5.7 nm
Dmax 19.5 nm
VolumePorod 410 nm3

SASDDA8 – Apolipoprotein E4

Apolipoprotein E4 experimental SAS data
Apolipoprotein E4 Kratky plot
Sample: Apolipoprotein E4 tetramer, 139 kDa Homo sapiens protein
Buffer: 20 mM HEPES, 300 mM NaCl, pH: 8
Experiment: SAXS data collected at B21, Diamond Light Source on 2017 Nov 29
RgGuinier 5.8 nm
Dmax 19.6 nm
VolumePorod 430 nm3