Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses.

Stachowski T, Grant TD, Snell EH
J Synchrotron Radiat 26(Pt 4):967-979 (2019 Jul 1)
PMID: 31274418
doi: 10.1107/S1600577519005113 		Submitted to SASBDB: 2019 Jan 29
Published in SASBDB:

SASDFD2 – wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1)

Human Latent Transforming Growth Factor beta 1 experimental SAS data
Human Latent Transforming Growth Factor beta 1 Kratky plot
Sample: Human Latent Transforming Growth Factor beta 1 dimer, 86 kDa Homo sapiens protein
Buffer: phosphate buffered saline 2% glycerol, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2018 Oct 4
RgGuinier 3.8 nm
Dmax 17.5 nm
VolumePorod 200 nm3

SASDFE2 – wild-type human Latency Associated Peptide (LAP)

Latency Associated Peptide experimental SAS data
Latency Associated Peptide Kratky plot
Sample: Latency Associated Peptide dimer, 58 kDa Homo sapiens protein
Buffer: phosphate buffered saline, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2018 Oct 4
RgGuinier 4.1 nm
Dmax 17.5 nm
VolumePorod 179 nm3