Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives

Lopes R, Tomé C, Russo R, Paterna R, Leandro J, Candeias N, Gonçalves L, Teixeira M, Sousa P, Guedes R, Vicente J, Gois P, Leandro P
Biomolecules 11(3):462 (2021 Mar 19)

doi: 10.3390/biom11030462 		Submitted to SASBDB: 2019 Jun 6
Published in SASBDB:

SASDFB7 – Human phenylalanine hydroxylase (hPAH)

Phenylalanine-4-hydroxylase experimental SAS data
CORAL model
Sample: Phenylalanine-4-hydroxylase tetramer, 223 kDa Homo sapiens protein
Buffer: 0.02 mM Hepes, 0.2 M NaCl,, pH: 7
Experiment: SAXS data collected at B21, Diamond Light Source on 2016 Feb 25
RgGuinier 4.3 nm
Dmax 14.8 nm
VolumePorod 336 nm3

SASDFC7 – Human phenylalanine hydroxylase (hPAH) + 1 mM L-Phe

Phenylalanine-4-hydroxylase experimental SAS data
DAMMIN model
Sample: Phenylalanine-4-hydroxylase tetramer, 223 kDa Homo sapiens protein
Buffer: 0.02 mM Hepes, 0.2 M NaCl,, pH: 7
Experiment: SAXS data collected at B21, Diamond Light Source on 2016 Feb 25
RgGuinier 4.0 nm
Dmax 12.3 nm
VolumePorod 367 nm3