Structural basis for adhesion G protein-coupled receptor Gpr126 function

Leon K, Cunningham R, Riback J, Feldman E, Li J, Sosnick T, Zhao M, Monk K, Araç D
Nature Communications 11(1) (2020 Jan 10)

doi: 10.1038/s41467-019-14040-1

Submitted to SASBDB: 2019 Jul 18 Published in SASBDB: 2019 Dec 17

SASDFT9 – Adhesion G-protein coupled receptor G6 - zfGpr126 S2 (-ss) ECR Sample: Adhesion G-protein coupled receptor G6 S2 monomer, 86 kDa Danio rerio protein Buffer: 150 mM NaCl, 20 mM HEPES, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Jun 28 RgGuinier 4.0 nm Dmax 14.1 nm VolumePorod 169 nm3

SASDFU9 – Adhesion G-protein coupled receptor G6 - zfGpr126 S1 (+ss) ECR Sample: Adhesion G-protein coupled receptor G6 S1 monomer, 89 kDa Danio rerio protein Buffer: 150 mM NaCl, 20 mM HEPES, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Jun 28 RgGuinier 4.2 nm Dmax 14.8 nm VolumePorod 191 nm3

SASDFV9 – Adhesion G-protein coupled receptor G6 - zfGpr126 S2 (-ss) D134A/F135A ECR Sample: Adhesion G-protein coupled receptor G6 S2 D134A/F135A monomer, 86 kDa Danio rerio protein Buffer: 150 mM NaCl, 20 mM HEPES, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Jun 28 RgGuinier 4.3 nm Dmax 14.8 nm VolumePorod 181 nm3

SASDFW9 – Adhesion G-protein coupled receptor G6 - hGPR126 S2 (-ss) ECR Sample: Adhesion G-protein coupled receptor G6 S2 monomer, 88 kDa Homo sapiens protein Buffer: 150 mM NaCl, 20 mM HEPES, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Jun 28 RgGuinier 4.4 nm Dmax 15.7 nm VolumePorod 199 nm3

SASDFX9 – Adhesion G-protein coupled receptor G6 - hGPR126 S1 (+ss) ECR Sample: Adhesion G-protein coupled receptor G6 S1 monomer, 91 kDa Homo sapiens protein Buffer: 150 mM NaCl, 20 mM HEPES, pH: 7.5 Experiment: SAXS data collected at BioCAT 18ID, Advanced Photon Source (APS), Argonne National Laboratory on 2018 Jun 28 RgGuinier 4.9 nm Dmax 17.1 nm VolumePorod 213 nm3