Small Angle Scattering Biological Data Bank SASBDB


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3 hits found for Vu

SASDU47 – Non-homologous end-joining factor 1 - XLF

Non-homologous end-joining factor 1 experimental SAS data

Non-homologous end-joining factor 1 Kratky plot

Sample:	Non-homologous end-joining factor 1 dimer, 67 kDa Homo sapiens protein
Buffer:	20 mM Bis-tris, 150 mM KCl, 1 mM EDTA, 1 mM DTT, pH: 6.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2021 Mar 13

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro. Nat Struct Mol Biol (2024)
Vu DD, Bonucci A, Brenière M, Cisneros-Aguirre M, Pelupessy P, Wang Z, Carlier L, Bouvignies G, Cortes P, Aggarwal AK, Blackledge M, Gueroui Z, Belle V, Stark JM, Modesti M, Ferrage F

R_g^Guinier	3.6	nm
D_max	12.1	nm
Volume^Porod	123	nm³

SASDU57 – DNA repair protein XRCC4 in complex with BRCT domains of DNA ligase 4

DNA repair protein XRCC4DNA ligase 4 experimental SAS data

DNA repair protein XRCC4 DNA ligase 4 Kratky plot

Sample:	DNA repair protein XRCC4 dimer, 77 kDa Homo sapiens protein DNA ligase 4 monomer, 31 kDa Homo sapiens protein
Buffer:	20 mM Bis-tris, 150 mM KCl, 1 mM EDTA, 1 mM DTT, pH: 6.5
Experiment:	SAXS data collected at SWING, SOLEIL on 2021 Mar 13

R_g^Guinier	5.8	nm
D_max	23.0	nm
Volume^Porod	248	nm³

SASDU67 – The C-terminal region of DNA repair protein XRCC4

DNA repair protein XRCC4 experimental SAS data

Sample:	DNA repair protein XRCC4 monomer, 15 kDa Homo sapiens protein
Buffer:	20 mM Bis-tris, 150 mM KCl, 1 mM EDTA, 1 mM DTT, pH: 6.5
Experiment:	SAXS data collected at B21, Diamond Light Source on 2021 Oct 20

R_g^Guinier	3.4	nm
D_max	11.1	nm
Volume^Porod	41	nm³

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SASDU47 – Non-homologous end-joining factor 1 - XLF

SASDU57 – DNA repair protein XRCC4 in complex with BRCT domains of DNA ligase 4

SASDU67 – The C-terminal region of DNA repair protein XRCC4