Small Angle Scattering Biological Data Bank SASBDB


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16 hits found for Human immunoglobulin ChiLob 7/4 - kappa chain

SASDWN2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chainHuman immunoglobulin ChiLob 7/4 - kappa chain experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain Human immunoglobulin ChiLob 7/4 - kappa chain Kratky plot

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain dimer, 99 kDa Homo sapiens protein Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Sep 28

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism. Nat Commun 16(1):3495 (2025)
Elliott IG, Fisher H, Chan HTC, Inzhelevskaya T, Mockridge CI, Penfold CA, Duriez PJ, Orr CM, Herniman J, Müller KTJ, Essex JW, Cragg MS, Tews I

R_g^Guinier	4.9	nm
D_max	16.0	nm
Volume^Porod	202	nm³

SASDWP2 – Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4

Human immunoglobulin ChiLob 7/4 - kappa chainHuman immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain experimental SAS data

Human immunoglobulin ChiLob 7/4 - kappa chain Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain Kratky plot

Sample:	Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 - heavy chain dimer, 99 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Sep 28

R_g^Guinier	5.1	nm
D_max	16.6	nm
Volume^Porod	214	nm³

SASDWQ2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224SHuman immunoglobulin ChiLob 7/4 - kappa chain C214S experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S Human immunoglobulin ChiLob 7/4 - kappa chain C214S Kratky plot

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S dimer, 99 kDa Homo sapiens protein Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Sep 28

R_g^Guinier	4.9	nm
D_max	16.0	nm
Volume^Porod	204	nm³

SASDWR2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S kappa chain C214S mutant

Human immunoglobulin ChiLob 7/4 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S experimental SAS data

Human immunoglobulin ChiLob 7/4 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S Kratky plot

Sample:	Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C225S dimer, 99 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Sep 28

R_g^Guinier	4.9	nm
D_max	16.0	nm
Volume^Porod	209	nm³

SASDWS2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S kappa chain C214S mutant

Human immunoglobulin ChiLob 7/4 - kappa chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S experimental SAS data

Human immunoglobulin ChiLob 7/4 - kappa chain C214S Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S Kratky plot

Sample:	Human immunoglobulin ChiLob 7/4 - kappa chain C214S dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain K223C/C224S dimer, 99 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Sep 28

R_g^Guinier	4.9	nm
D_max	15.3	nm
Volume^Porod	204	nm³

SASDWT2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S kappa chain E123C/C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224SHuman immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S Human immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S Kratky plot

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain T219C/C224S dimer, 99 kDa Homo sapiens protein Human immunoglobulin ChiLob 7/4 - kappa chain E123C/C214S dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Sep 28

R_g^Guinier	4.8	nm
D_max	15.1	nm
Volume^Porod	205	nm³

SASDWU2 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S mutant

Human immunoglobulin ChiLob 7/4 - kappa chainHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S experimental SAS data

Human immunoglobulin ChiLob 7/4 - kappa chain Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S Kratky plot

Sample:	Human immunoglobulin ChiLob 7/4 - kappa chain dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 - heavy chain C224S/C225S dimer, 99 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2024 Nov 29

R_g^Guinier	5.0	nm
D_max	16.5	nm
Volume^Porod	215	nm³

SASDLK4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S, kappa chain C214S mutant

ChiLob 7/4 IgG2 F(ab)2 C224S/kC214S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S, kappa chain C214S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C224S/kC214S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

...human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility Science Immunology 7(73) (2022)
Orr C, Fisher H, Yu X, Chan C, Gao Y, Duriez P, Booth S, Elliott I, Inzhelevskaya T, Mockridge I, Penfold C, Wagner A, Glennie M, White A, Essex J, Pearson A, Cragg M, Tews I

R_g^Guinier	4.0	nm
D_max	13.3	nm
Volume^Porod	133	nm³

SASDLL4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C225S, kappa chain C214S mutant

ChiLob 7/4 IgG2 F(ab)2 C225S/kC214S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C225S, kappa chain C214S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C225S/kC214S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

R_g^Guinier	4.0	nm
D_max	13.7	nm
Volume^Porod	130	nm³

SASDSC7 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain T219C/C224S kappa chain E123C/C214S

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain T219C/C224SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa chain E123C/C214S experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain T219C/C224S kappa chain E123C/C214S Rg histogram

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain T219C/C224S dimer, 52 kDa protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa chain E123C/C214S dimer, 47 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Apr 12

R_g^Guinier	3.9	nm
D_max	13.2	nm
Volume^Porod	124	nm³

SASDSD7 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain K223C/C224S kappa chain C214S

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain K223C/C224SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214S experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain K223C/C224S kappa chain C214S Rg histogram

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain K223C/C224S dimer, 52 kDa protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214S dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Apr 12

R_g^Guinier	3.9	nm
D_max	13.2	nm
Volume^Porod	124	nm³

SASDUG8 – Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2

Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chainHuman immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data

Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chain Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain Kratky plot

Sample:	Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - heavy chain dimer, 51 kDa Homo sapiens protein Human immunoglobulin gamma 1 (IgG1) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Apr 12

R_g^Guinier	4.6	nm
D_max	17.4	nm
Volume^Porod	133	nm³

SASDUH8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chainHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain Kratky plot

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain dimer, 52 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Jun 8

R_g^Guinier	3.9	nm
D_max	13.7	nm
Volume^Porod	123	nm³

SASDUJ8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S mutant Rg histogram

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S/C225S dimer, 52 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain dimer, 47 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Apr 12

R_g^Guinier	4.2	nm
D_max	14.8	nm
Volume^Porod	127	nm³

SASDUK8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S experimental SAS data

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214S dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C225S dimer, 52 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Apr 12

R_g^Guinier	4.0	nm
D_max	14.1	nm
Volume^Porod	125	nm³

SASDUL8 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S kappa chain C214S mutant

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214SHuman immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S experimental SAS data

Sample:	Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - kappa light chain C214S dimer, 47 kDa Homo sapiens protein Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab')2 - heavy chain C224S dimer, 52 kDa Homo sapiens protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2022 Apr 12

R_g^Guinier	3.9	nm
D_max	13.9	nm
Volume^Porod	126	nm³

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