SASBDB entries for UniProt ID: P01137

SASDFD2 – wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1)

UniProt ID: P01137 (30-390) Human Latent Transforming Growth Factor beta 1
Human Latent Transforming Growth Factor beta 1 experimental SAS data
Human Latent Transforming Growth Factor beta 1 Kratky plot
Sample: Human Latent Transforming Growth Factor beta 1 dimer, 86 kDa Homo sapiens protein
Buffer: phosphate buffered saline 2% glycerol, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2018 Oct 4
Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses. J Synchrotron Radiat 26(Pt 4):967-979 (2019)
Stachowski T, Grant TD, Snell EH
RgGuinier 3.8 nm
Dmax 17.5 nm
VolumePorod 200 nm3

SASDFE2 – wild-type human Latency Associated Peptide (LAP)

UniProt ID: P01137 (30-278) Latency Associated Peptide
Latency Associated Peptide experimental SAS data
Latency Associated Peptide Kratky plot
Sample: Latency Associated Peptide dimer, 58 kDa Homo sapiens protein
Buffer: phosphate buffered saline, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2018 Oct 4
Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses. J Synchrotron Radiat 26(Pt 4):967-979 (2019)
Stachowski T, Grant TD, Snell EH
RgGuinier 4.1 nm
Dmax 17.5 nm
VolumePorod 179 nm3

SASDG55 – Deglycosylated latency associated peptide, LAP (TGFB-1)

UniProt ID: P01137 (30-277) Latency associated peptide
Latency associated peptide experimental SAS data
Latency associated peptide Kratky plot
Sample: Latency associated peptide dimer, 58 kDa Homo sapiens protein
Buffer: phosphate buffered saline 2% glycerol, pH: 7.4
Experiment: SAXS data collected at 12.3.1 (SIBYLS), Advanced Light Source (ALS) on 2019 Apr 20
Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states IUCrJ 7(2) (2020)
Stachowski T, Snell M, Snell E
RgGuinier 3.5 nm
Dmax 13.0 nm
VolumePorod 129 nm3