SASDSB5 – light-state short-linker LOV-activated diguanylate cyclase

Diguanylate cyclase experimental SAS data
Diguanylate cyclase Kratky plot
Sample: Diguanylate cyclase dimer, 67 kDa Aquella oligotrophica protein
Buffer: 10 mM Tris, 500 mM NaCl, 2 mM MgCl2, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2023 May 4
Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases Science Advances 9(31) (2023)
Vide U, Kasapović D, Fuchs M, Heimböck M, Totaro M, Zenzmaier E, Winkler A
RgGuinier 3.4 nm
Dmax 15.7 nm
VolumePorod 104 nm3

SASDSC5 – dark-state long-linker LOV-activated diguanylate cyclase

Sensor domain-containing diguanylate cyclase experimental SAS data
GASBOR model
Sample: Sensor domain-containing diguanylate cyclase dimer, 72 kDa Methylotenera sp. protein
Buffer: 10 mM Tris, 50 mM NaCl, 2 mM MgCl2, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2023 May 4
Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases Science Advances 9(31) (2023)
Vide U, Kasapović D, Fuchs M, Heimböck M, Totaro M, Zenzmaier E, Winkler A
RgGuinier 2.9 nm
Dmax 11.1 nm
VolumePorod 115 nm3

SASDSD5 – light-state long-linker LOV-activated diguanylate cyclase

Sensor domain-containing diguanylate cyclase experimental SAS data
Sensor domain-containing diguanylate cyclase Kratky plot
Sample: Sensor domain-containing diguanylate cyclase dimer, 72 kDa Methylotenera sp. protein
Buffer: 10 mM Tris, 50 mM NaCl, 2 mM MgCl2, pH: 8
Experiment: SAXS data collected at BM29, ESRF on 2023 May 4
Illuminating the inner workings of a natural protein switch: Blue-light sensing in LOV-activated diguanylate cyclases Science Advances 9(31) (2023)
Vide U, Kasapović D, Fuchs M, Heimböck M, Totaro M, Zenzmaier E, Winkler A
RgGuinier 3.5 nm
Dmax 13.8 nm
VolumePorod 123 nm3

SASDM55 – GTP-binding domain of Candida albicans Ras-like protein 1

GTP-binding domain of Ras-like protein 1 experimental SAS data
MODELLER model
Sample: GTP-binding domain of Ras-like protein 1 monomer, 19 kDa protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% glycerol, 3 mM DTT, 5 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 1.6 nm
Dmax 4.1 nm
VolumePorod 26 nm3

SASDM65 – Candida albicans Ras-like protein 1

Ras-like protein 1 experimental SAS data
Candida albicans Ras-like protein 1 Rg histogram
Sample: Ras-like protein 1 monomer, 33 kDa Candida albicans protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 5% glycerol, 3 mM DTT, 5 mM MgCl2, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.6 nm
Dmax 15.1 nm
VolumePorod 56 nm3

SASDM75 – Ras-like protein 1 guanine nucleotide exchange factor region of Candida albicans cell division control protein 25

Cell division control protein 25 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.2 nm
Dmax 11.8 nm
VolumePorod 81 nm3

SASDM85 – GTP-binding domain of Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25

GTP-binding domain of Ras-like protein 1Cell division control protein 25 experimental SAS data
PDB (PROTEIN DATA BANK) model
Sample: GTP-binding domain of Ras-like protein 1 monomer, 19 kDa protein
Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 1 mM EDTA, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 3.2 nm
Dmax 11.8 nm
VolumePorod 99 nm3

SASDM95 – Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25

Ras-like protein 1Cell division control protein 25 experimental SAS data
Candida albicans Ras-like protein 1 in complex with the guanine nucleotide exchange factor region of cell division control protein 25 Rg histogram
Sample: Ras-like protein 1 monomer, 33 kDa Candida albicans protein
Cell division control protein 25 monomer, 55 kDa Candida albicans (strain … protein
Buffer: 20 mM Na-phosphate, 150 mM NaCl, 1 mM EDTA, 5% glycerol, 3 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2020 Jun 21
Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets. mBio :e0063823 (2023)
Manso JA, Carabias A, Sárkány Z, de Pereda JM, Pereira PJB, Macedo-Ribeiro S
RgGuinier 4.0 nm
Dmax 17.7 nm
VolumePorod 149 nm3

SASDSY6 – Outer membrane protein MIP (LpMIP) apo state

Outer membrane protein MIP experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16
Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding International Journal of Biological Macromolecules :126366 (2023)
Wiedemann C, Whittaker J, Carrillo V, Goretzki B, Dajka M, Tebbe F, Harder J, Krajczy P, Joseph B, Hausch F, Guskov A, Hellmich U
RgGuinier 3.1 nm
Dmax 10.0 nm
VolumePorod 66 nm3

SASDSZ6 – Outer membrane protein MIP (LpMIP) with bound inhibitor JK095

Outer membrane protein MIP experimental SAS data
SREFLEX model
Sample: Outer membrane protein MIP dimer, 46 kDa Legionella pneumophila subsp. … protein
Buffer: 20 mM Tris-HCl, 150 mM NaCl, 10 mM DTT, pH: 7.5
Experiment: SAXS data collected at EMBL P12, PETRA III on 2021 Mar 16
Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding International Journal of Biological Macromolecules :126366 (2023)
Wiedemann C, Whittaker J, Carrillo V, Goretzki B, Dajka M, Tebbe F, Harder J, Krajczy P, Joseph B, Hausch F, Guskov A, Hellmich U
RgGuinier 3.1 nm
Dmax 10.2 nm
VolumePorod 65 nm3

4692 hits found.