Small Angle Scattering Biological Data Bank SASBDB

SASDNP3 – Recombinant phospholipase A2 receptor at pH 7.2

Secretory phospholipase A2 receptor experimental SAS data

Secretory phospholipase A2 receptor Kratky plot

Sample:	Secretory phospholipase A2 receptor monomer, 189 kDa Homo sapiens protein
Buffer:	10 mM Bis-Tris, 150 mM NaCl, pH: 7.2
Experiment:	SAXS data collected at B21, Diamond Light Source on 2019 Dec 19

Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch Proceedings of the National Academy of Sciences 119(29) (2022)
Fresquet M, Lockhart-Cairns M, Rhoden S, Jowitt T, Briggs D, Baldock C, Brenchley P, Lennon R

R_g^Guinier	5.9	nm
D_max	26.0	nm
Volume^Porod	504	nm³

SASDNQ3 – Recombinant phospholipase A2 receptor at pH 6.2

Sample:	Secretory phospholipase A2 receptor monomer, 189 kDa Homo sapiens protein
Buffer:	10 mM Bis-Tris, 150 mM NaCl, pH: 6.2
Experiment:	SAXS data collected at B21, Diamond Light Source on 2019 Dec 19

R_g^Guinier	4.2	nm
D_max	15.8	nm
Volume^Porod	426	nm³

SASDLF4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S mutant

ChiLob 7/4 IgG2 F(ab)2 C224S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C224S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility Science Immunology 7(73) (2022)
Orr C, Fisher H, Yu X, Chan C, Gao Y, Duriez P, Booth S, Elliott I, Inzhelevskaya T, Mockridge I, Penfold C, Wagner A, Glennie M, White A, Essex J, Pearson A, Cragg M, Tews I

R_g^Guinier	3.9	nm
D_max	14.2	nm
Volume^Porod	135	nm³

SASDLG4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S+C225S mutant

ChiLob 7/4 IgG2 F(ab)2 C224S/C225S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S+C225S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C224S/C225S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

R_g^Guinier	4.2	nm
D_max	15.1	nm
Volume^Porod	135	nm³

SASDLH4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C225S mutant

ChiLob 7/4 IgG2 F(ab)2 C225S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C225S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C225S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

R_g^Guinier	4.0	nm
D_max	14.5	nm
Volume^Porod	131	nm³

SASDLJ4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C228S mutant

ChiLob 7/4 IgG2 F(ab)2 C228S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C228S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C228S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

R_g^Guinier	4.1	nm
D_max	13.5	nm
Volume^Porod	135	nm³

SASDLK4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S, kappa chain C214S mutant

ChiLob 7/4 IgG2 F(ab)2 C224S/kC214S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C224S, kappa chain C214S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C224S/kC214S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

R_g^Guinier	4.0	nm
D_max	13.3	nm
Volume^Porod	133	nm³

SASDLL4 – Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C225S, kappa chain C214S mutant

ChiLob 7/4 IgG2 F(ab)2 C225S/kC214S mutant experimental SAS data

Human immunoglobulin gamma 2 (IgG2) ChiLob 7/4 F(ab)2 - Heavy chain C225S, kappa chain C214S mutant Rg histogram

Sample:	ChiLob 7/4 IgG2 F(ab)2 C225S/kC214S mutant monomer, 99 kDa protein
Buffer:	50 mM HEPES, 150 mM KCl, pH: 7.5
Experiment:	SAXS data collected at BM29, ESRF on 2018 Feb 9

R_g^Guinier	4.0	nm
D_max	13.7	nm
Volume^Porod	130	nm³

SASDJX7 – Labrum-Interacting Proteins from Saliva 2 (34k-2) - SEC-SAXS

Similar to Aedes aegypti 34 kDa salivary secreted protein 34k-2 experimental SAS data

Sample:	Similar to Aedes aegypti 34 kDa salivary secreted protein 34k-2 monomer, 35 kDa Aedes albopictus protein
Buffer:	25 mM HEPES, 0.1 M NaCl, pH: 8
Experiment:	SAXS data collected at BM29, ESRF on 2016 Sep 3

A salivary factor binds a cuticular protein and modulates biting by inducing morphological changes in the mosquito labrum. Curr Biol (2022)
Arnoldi I, Mancini G, Fumagalli M, Gastaldi D, D'Andrea L, Bandi C, Di Venere M, Iadarola P, Forneris F, Gabrieli P

R_g^Guinier	2.7	nm
D_max	8.4	nm
Volume^Porod	50	nm³

SASDLC9 – 2-aminomuconic 6-semialdehyde dehydrogenase double truncation mutant (Δ124-138; Δ477-491)

2-aminomuconic 6-semialdehyde dehydrogenase experimental SAS data

Sample:	2-aminomuconic 6-semialdehyde dehydrogenase dimer, 101 kDa Pseudomonas sp. protein
Buffer:	20 mM HEPES, 150 mM NaCl, pH: 7
Experiment:	SAXS data collected at BL19U2, Shanghai Synchrotron Radiation Facility (SSRF) on 2021 Feb 1

The tetrameric assembly of 2-aminomuconic 6-semialdehyde dehydrogenase is a functional requirement of cofactor NAD(+) binding. Environ Microbiol 24(7):2994-3012 (2022)
Shi Q, Chen Y, Li X, Dong H, Chen C, Zhong Z, Yang C, Liu G, Su D

R_g^Guinier	2.9	nm
D_max	9.0	nm
Volume^Porod	117	nm³

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